Gene Symbol | FAAH |
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Entrez Gene | 2166 |
Alt Symbol | FAAH-1, PSAB |
Species | Human |
Gene Type | protein-coding |
Description | fatty acid amide hydrolase |
Other Description | anandamide amidohydrolase 1|fatty-acid amide hydrolase 1|oleamide hydrolase 1 |
Swissprots | Q52M86 Q5TDF8 D3DQ19 O00519 |
Accessions | AAD13768 AAV88095 O00519 AL050372 CAB62530 BC034478 BC093632 AAH93632 BC110404 AAI10405 BC111941 AAI11942 BG718115 U82535 AAB58505 NM_001441 NP_001432 |
Function | Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. {ECO:0000269|PubMed:17015445}. |
Subcellular Location | Endomembrane system {ECO:0000269|PubMed:17015445}; Single-pass membrane protein {ECO:0000269|PubMed:17015445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17015445}. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network. |
Tissue Specificity | Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. {ECO:0000269|PubMed:17015445}. |
Top Pathways | Retrograde endocannabinoid signaling |
FAAH1 peptide - ab107909 from Abcam
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Human FAAH1 protein fragment - ab114426 from Abcam
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FAAH-Antibody-C-term-Blocking-Peptide - BP17046b from Abgent, a WuXi AppTec company
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FAAH-Antibody-N-term-Blocking-Peptide - BP18148a from Abgent, a WuXi AppTec company
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Oleamide hydrolase 1 - H00002166-Q01-10 from Acris Antibodies
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Oleamide hydrolase 1 - H00002166-Q01-25 from Acris Antibodies
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FAAH fusion protein - Ag12304 from Proteintech Group
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FAAH fusion protein - ag12720 from Proteintech Group
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FAAH Peptide - 350551 from ABBIOTEC
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Recombinant Human FAAH, GST-tagged - FAAH-26642TH from Creative Biomart
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Recombinant Human FAAH, GST-tagged - FAAH-12629H from Creative Biomart
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Recombinant Human FAAH protein, His-tagged - FAAH-19H from Creative Biomart
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Recombinant Human FAAH, MYC/DDK-tagged - FAAH-20H from Creative Biomart
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Recombinant Human FAAH - FAAH-621H from Creative Biomart
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Recombinant Human Fatty-acid amide hydrolase 1(FAAH),partial - CSB-YP007938HU CSB-EP007938HU CSB-BP007938HU CSB-MP007938HU from Cusabio
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Oleamide hydrolase 1 - TP310331 from Acris Antibodies
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Fatty-acid amide hydrolase 1, Recombinant Protein - MBS7042701 from MyBioSource
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Fatty-acid amide hydrolase 1 (FAAH), Recombinant Protein - MBS1067676 from MyBioSource
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Fatty Acid Amide Hyrdrolase 1 (FAAH1), Active, Human Recombinant - P1257 from Biovision
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