| Gene Symbol |
WRN
|
| Entrez Gene |
7486
|
| Alt Symbol |
RECQ3, RECQL2, RECQL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Werner syndrome, RecQ helicase-like
|
| Other Description |
DNA helicase, RecQ-like type 3|Werner syndrome ATP-dependent helicase|exonuclease WRN|recQ protein-like 2
|
| Swissprots |
A1KYY9 Q14191
|
| Accessions |
AAC41981 AAF06162 AAR05448 EAW63424 EAW63425 EAW63426 Q14191 AB209652 BAD92889 AF091214 AAC63361 AL833572 AY818673 AAX21098 BP279291 XM_011544639 XP_011542941 XM_011544640 XP_011542942 XR_949470 XR_949471 XR_949472 NM_000553 NP_000544
|
| Function |
Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. {ECO:0000250, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|
|
| Subcellular Location |
Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation- induced WRN relocation.
|