WRN

Gene Symbol	WRN
Entrez Gene	7486
Alt Symbol	RECQ3, RECQL2, RECQL3
Species	Human
Gene Type	protein-coding
Description	Werner syndrome, RecQ helicase-like
Other Description	DNA helicase, RecQ-like type 3|Werner syndrome ATP-dependent helicase|exonuclease WRN|recQ protein-like 2
Swissprots	A1KYY9 Q14191
Accessions	AAC41981 AAF06162 AAR05448 EAW63424 EAW63425 EAW63426 Q14191 AB209652 BAD92889 AF091214 AAC63361 AL833572 AY818673 AAX21098 BP279291 XM_011544639 XP_011542941 XM_011544640 XP_011542942 XR_949470 XR_949471 XR_949472 NM_000553 NP_000544
Function	Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. {ECO:0000250, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|
Subcellular Location	Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation- induced WRN relocation.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Werner's syndrome helicase WRN protein fragment - ab112372 from Abcam Category Protein Source Wheat germ Species Human

Mouse Werner's syndrome helicase WRN peptide - ab19370 from Abcam Category Peptide

WRN Antibody Blocking Peptide - LS-E1412 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WRN Protein - H00007486-Q01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

WRN-Antibody-Center-T802-Blocking-peptide - BP12078c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WRN - H00007486-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

WRN Peptide - 350527 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human WRN - WRN-30699TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human Werner syndrome ATP-dependent helicase(WRN) ,partial - CSB-YP614518HU CSB-EP614518HU CSB-BP614518HU CSB-MP614518HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Werner syndrome ATP-dependent helicase(WRN) ,partial, Recombinant Protein - MBS1412762 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

WRN Protein - NBP1-87143PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

WRN Blocking Peptide (OESA09499) - OESA09499 from Aviva Systems Biology Category Peptide Prices $245.00 Sizes 50 µg Species Human

WRN Peptide, Human - M34GP17533H from Creative Peptides Category Peptide Source Synthetic. Species Human

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