WRN

Gene Symbol WRN
Entrez Gene 7486
Alt Symbol RECQ3, RECQL2, RECQL3
Species Human
Gene Type protein-coding
Description Werner syndrome, RecQ helicase-like
Other Description DNA helicase, RecQ-like type 3|Werner syndrome ATP-dependent helicase|exonuclease WRN|recQ protein-like 2
Swissprots A1KYY9 Q14191
Accessions AAC41981 AAF06162 AAR05448 EAW63424 EAW63425 EAW63426 Q14191 AB209652 BAD92889 AF091214 AAC63361 AL833572 AY818673 AAX21098 BP279291 XM_011544639 XP_011542941 XM_011544640 XP_011542942 XR_949470 XR_949471 XR_949472 NM_000553 NP_000544
Function Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. {ECO:0000250, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|
Subcellular Location Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation- induced WRN relocation.

WRN CRISPR/Cas9 KO Plasmid (h) - sc-401860 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN HDR Plasmid (h) - sc-401860-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN Double Nickase Plasmid (h) - sc-401860-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN Double Nickase Plasmid (h2) - sc-401860-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN CRISPR Activation Plasmid (h) - sc-401860-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN CRISPR Activation Plasmid (h2) - sc-401860-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN Lentiviral Activation Particles (h) - sc-401860-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN Lentiviral Activation Particles (h2) - sc-401860-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WRN siRNA (h) - sc-36843 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WRN shRNA Plasmid (h) - sc-36843-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WRN shRNA (h) Lentiviral Particles - sc-36843-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WRN RNAi - H00007486-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU048411 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1746 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1746 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

WRN siRNA (Human) - CRH5125 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WRN - MBS8205733 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human WRN (NM_000553.4) - SHH447452 from Creative biogene

Category siRNA
Species Reactivities Human

WRN shRNA Plasmid (Human) - CHH5125 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

WRN miRNA 3'UTR clone - MiUTR3H-06956 from Creative biogene

Species Reactivities Human
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