| Gene Symbol |
MCM5
|
| Entrez Gene |
4174
|
| Alt Symbol |
CDC46, P1-CDC46
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 5
|
| Other Description |
CDC46 homolog|DNA replication licensing factor MCM5|MCM5 minichromosome maintenance deficient 5, cell division cycle 46|minichromosome maintenance deficient 5 (cell division cycle 46)
|
| Swissprots |
Q9BTJ4 O60785 P33992 Q14578 Q9BWL8
|
| Accessions |
AAO21127 CBX85478 EAW60060 EAW60061 EAW60062 EAW60063 P33992 AB209612 BAD92849 AK122853 BAG53762 AK130620 AK223323 BAD97043 AK291136 BAF83825 AK298624 BAG60801 AK301121 BAG62717 AK308343 AK312533 BAG35432 BC000142 AAH00142 BC003656 AAH03656 BM787690 CR456517 CAG30403 CU013117 CAK54548 CU013405 CAK54847 D83986 BAA12176 X74795 CAA52802 XM_006724242 XP_006724305 NM_006739 NP_006730
|
| Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP. {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
DNA replication, Cell cycle
|