MCM5

Gene Symbol MCM5
Entrez Gene 4174
Alt Symbol CDC46, P1-CDC46
Species Human
Gene Type protein-coding
Description minichromosome maintenance complex component 5
Other Description CDC46 homolog|DNA replication licensing factor MCM5|MCM5 minichromosome maintenance deficient 5, cell division cycle 46|minichromosome maintenance deficient 5 (cell division cycle 46)
Swissprots Q9BTJ4 O60785 P33992 Q14578 Q9BWL8
Accessions AAO21127 CBX85478 EAW60060 EAW60061 EAW60062 EAW60063 P33992 AB209612 BAD92849 AK122853 BAG53762 AK130620 AK223323 BAD97043 AK291136 BAF83825 AK298624 BAG60801 AK301121 BAG62717 AK308343 AK312533 BAG35432 BC000142 AAH00142 BC003656 AAH03656 BM787690 CR456517 CAG30403 CU013117 CAK54548 CU013405 CAK54847 D83986 BAA12176 X74795 CAA52802 XM_006724242 XP_006724305 NM_006739 NP_006730
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP. {ECO:0000250}.
Subcellular Location Nucleus.
Top Pathways DNA replication, Cell cycle

MCM5 (33) - sc-136366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM5 (33): sc-136366. Western blot analysis of MCM5 expression in HeLa whole cell lysate.

MCM5 (C-10) - sc-165993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM5 (C-10): sc-165993. Western blot analysis of MCM5 expression in non-transfected: sc-110760 (A) and human MCM5 transfected: sc-110497 (B) 293 whole cell lysates and HL-60 (C) and KNRK (D) nuclear extracts.

MCM5 (E-10) - sc-165994 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM5 (E-10): sc-165994. Western blot analysis of MCM5 expression in non-transfected: sc-110760 (A) and human MCM5 transfected: sc-110497 (B) 293 whole cell lysates and HL-60 (C) and KNRK (D) nuclear extracts.

MCM5 (G-1) - sc-165995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM5 (G-1): sc-165995. Western blot analysis of MCM5 expression in non-transfected: sc-110760 (A) and human MCM5 transfected: sc-110497 (B) 293 whole cell lysates and HL-60 (C) and KNRK (D) nuclear extracts.

MCM5 (H-300) - sc-22780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MCM5 (H-300): sc-22780. Western blot analysis of MCM5 expression in HL-60 nuclear extract.

MCM5 (N-19) - sc-8281 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MCM5 (N-19): sc-8281. Western blot analysis of MCM5 expression in KNRK nuclear extract.

Anti-MCM5 antibody - ab17967 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung carcinoma (left) and mouse renal cell carcinoma (right) tissues labelling MCM5 with ab17967 at 1/1000 (1µg/ml). Detection: DAB.

Anti-MCM5 antibody - ab154340 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MCM5 antibody (ab154340) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-MCM5 antibody - ab53140 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MCM5 antibody (ab53140) at 1/500 dilutionLane 1 : HepG2 cell lysate minus immunising peptideLane 2 : HepG2 cell lysate plus immunising peptide

Anti-MCM5 antibody - ab40093 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab40093 at a 1:100 dilution staining MCM5 in Human prostate tissue.

Anti-MCM5 antibody - ab171981 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MCM5 antibody (ab171981) at 1 µg/mlLane 1 : MCM5 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateSecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-MCM5 antibody [A2.9B4.B12.D8.B8] - ab119277 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A2.9B4.B12.D8.B8

Anti-MCM5 antibody [CRCT5.1 (A2.7A3)] - ab6154 from Abcam

Prices $379.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone CRCT5.1 (A2.7A3)
ab6154 staining MCM5 in human tonsil by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-MCM5 antibody [EP2682Y] - ab76023 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2682Y
All lanes : Anti-MCM5 antibody [EP2682Y] (ab76023) at 1/2000 dilutionLane 1 : Hela cell lysateLane 2 : MCF7 cell lysateLane 3 : Human spleen lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-MCM5 antibody [EP2683Y] - ab75975 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2683Y
All lanes : Anti-MCM5 antibody [EP2683Y] (ab75975) at 1/10000 dilutionLane 1 : HeLa lysateLane 2 : MCF7 cell lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-MCM5 antibody, prediluted - ab53900 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Human prostate tissue stained with neat ab53900

Anti-MCM5 Antibody (C-Terminus, clone EP2683Y) - LS-C105340 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2683Y
IHC of paraffin-embedded human squamous cell cervical carcinoma using anti-MCM5 antibody. (LS-C105340).

Anti-MCM5 Antibody (aa1-50) - LS-C286316 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse MCM5 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-MCM5 used at a dilution of 1:250. Detection: DAB.

Anti-MCM5 Antibody (Phe51) - LS-C176113 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of MCM5 (F51) pAb in paraffin-embedded human tonsil tissue.

Anti-MCM5 Antibody - LS-C334137 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of U20S cell using MCM5 antibody. Blue: DAPI for nuclear staining.

Anti-MCM5 Antibody (aa720-734) - LS-C312808 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MCM5 antibody. IHC(P): Human Intestinal Cancer Tissue.

Anti-MCM5 Antibody IHC-plus™ - LS-B2509 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MCM5 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2509 dilution 1:50.

Anti-MCM5 Antibody (aa1-50) - LS-C287115 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse MCM5 by Immunohistochemistry. Sample: FFPE sections of human lung carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti-MCM5 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-MCM5 Antibody (clone CRCT5.1) IHC-plus™ - LS-B6277 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone CRCT5.1
Anti-MCM5 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6277 concentration 10 ug/ml.

Anti-MCM5 Antibody (N-Terminus) - LS-C31394 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate
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