| Gene Symbol |
KRT17
|
| Entrez Gene |
3872
|
| Alt Symbol |
K17, PC, PC2, PCHC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 17, type I
|
| Other Description |
39.1|CK-17|cytokeratin-17|keratin 17 epitope S1|keratin 17 epitope S2|keratin 17 epitope S4|keratin, type I cytoskeletal 17|keratin-17
|
| Swissprots |
A5Z1N0 A6NKQ2 Q6IP98 A6NDV6 A5Z1M9 Q8N1P6 A5Z1N1 A5Z1N2 Q04695
|
| Accessions |
AAB34565 AAD15003 CAA79626 EAW60750 EAW60751 EAW60752 EAW60753 Q04695 AK095342 BAC04534 AK304373 BAG65211 BC000159 AAH00159 BC011901 AAH11901 BC056421 AAH56421 BC072018 AAH72018 BC072019 AAH72019 BP226061 BX647923 DQ891101 ABM82027 DQ894283 ABM85209 EF608068 ABQ96595 EF608069 ABQ96596 EF608070 ABQ96597 EF608071 ABQ96598 X05803 CAA29248 X62571 CAA44451 NM_000422 NP_000413
|
| Function |
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions bein
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
|
| Tissue Specificity |
Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). {ECO:0000269|PubMed:10651700, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:1281771, ECO:0000269|PubMed:2481679}.
|
