KRT17

Gene Symbol	KRT17
Entrez Gene	3872
Alt Symbol	K17, PC, PC2, PCHC1
Species	Human
Gene Type	protein-coding
Description	keratin 17, type I
Other Description	39.1|CK-17|cytokeratin-17|keratin 17 epitope S1|keratin 17 epitope S2|keratin 17 epitope S4|keratin, type I cytoskeletal 17|keratin-17
Swissprots	A5Z1N0 A6NKQ2 Q6IP98 A6NDV6 A5Z1M9 Q8N1P6 A5Z1N1 A5Z1N2 Q04695
Accessions	AAB34565 AAD15003 CAA79626 EAW60750 EAW60751 EAW60752 EAW60753 Q04695 AK095342 BAC04534 AK304373 BAG65211 BC000159 AAH00159 BC011901 AAH11901 BC056421 AAH56421 BC072018 AAH72018 BC072019 AAH72019 BP226061 BX647923 DQ891101 ABM82027 DQ894283 ABM85209 EF608068 ABQ96595 EF608069 ABQ96596 EF608070 ABQ96597 EF608071 ABQ96598 X05803 CAA29248 X62571 CAA44451 NM_000422 NP_000413
Function	Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions bein
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
Tissue Specificity	Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). {ECO:0000269|PubMed:10651700, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:1281771, ECO:0000269|PubMed:2481679}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cytokeratin 17 CRISPR/Cas9 KO Plasmid (h) - sc-402008 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 HDR Plasmid (h) - sc-402008-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 Double Nickase Plasmid (h) - sc-402008-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 Double Nickase Plasmid (h2) - sc-402008-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 CRISPR Activation Plasmid (h) - sc-402008-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 CRISPR Activation Plasmid (h2) - sc-402008-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 Lentiviral Activation Particles (h) - sc-402008-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 Lentiviral Activation Particles (h2) - sc-402008-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cytokeratin 17 siRNA (h) - sc-43311 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cytokeratin 17 shRNA Plasmid (h) - sc-43311-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cytokeratin 17 shRNA (h) Lentiviral Particles - sc-43311-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cytokeratin 17 RNAi - H00003872-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU149311 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU106111 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU117911 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU118051 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11364 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11364 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

KRT17 siRNA (Human) - CRH2624 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human KRT17 (NM_000422.2) - SHH327279 from Creative biogene Category siRNA Species Reactivities Human

Human KRT17 siRNA - orb263126 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

KRT17 shRNA Plasmid (Human) - CHH2624 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KRT17 miRNA 3'UTR clone - MiUTR3H-01268 from Creative biogene Species Reactivities Human

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