KRT17

Gene Symbol KRT17
Entrez Gene 3872
Alt Symbol K17, PC, PC2, PCHC1
Species Human
Gene Type protein-coding
Description keratin 17, type I
Other Description 39.1|CK-17|cytokeratin-17|keratin 17 epitope S1|keratin 17 epitope S2|keratin 17 epitope S4|keratin, type I cytoskeletal 17|keratin-17
Swissprots A5Z1N0 A6NKQ2 Q6IP98 A6NDV6 A5Z1M9 Q8N1P6 A5Z1N1 A5Z1N2 Q04695
Accessions AAB34565 AAD15003 CAA79626 EAW60750 EAW60751 EAW60752 EAW60753 Q04695 AK095342 BAC04534 AK304373 BAG65211 BC000159 AAH00159 BC011901 AAH11901 BC056421 AAH56421 BC072018 AAH72018 BC072019 AAH72019 BP226061 BX647923 DQ891101 ABM82027 DQ894283 ABM85209 EF608068 ABQ96595 EF608069 ABQ96596 EF608070 ABQ96597 EF608071 ABQ96598 X05803 CAA29248 X62571 CAA44451 NM_000422 NP_000413
Function Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions bein
Subcellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
Tissue Specificity Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). {ECO:0000269|PubMed:10651700, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:1281771, ECO:0000269|PubMed:2481679}.

Keratin 17 (D73C7) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 8856 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D73C7
Confocal immunofluorescent analysis of HeLa (keratin 17 positive; left), HCC827 (keratin 17 negative, keratin 19 positive; middle), or SK-MEL-28 (keratin 17/19 negative; right) cells using Keratin 17 (D73C7) Rabbit mAb (Alexa Fluor® 647 Conjugate) (blue pseudocolor). Actin filaments were labeled with Alexa Fluor® 488 phalloidin (green). Red = Propidium Iodide (PI)/RNase Staining Solution #4087 (red).

Phospho-Keratin 17 (Ser44) Antibody - 3519 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cells, either untreated or treated with nocodazole, using Phospho-Keratin 17 (Ser44) Antibody (upper) or Keratin 17 #3984 (lower).

Keratin 17 (D12E5) XP ® Rabbit mAb - 12509 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D12E5
Western blot analysis of extracts from various cell lines using Keratin 17 (D12E5) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Keratin 17/19 (D4G2) XP ® Rabbit mAb - 12434 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4G2
Western blot analysis of extracts from various cell lines using Keratin 17/19 (D4G2) XP ® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Keratin 17/19 (D32D9) XP ® Rabbit mAb - 3984 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D32D9
Western blot analysis of extracts of HeLa, A549 and A431 cells using Keratin 17/19 (D32D9) XP ® Rabbit mAb. As expected, keratin 17 is detected in HeLa and A431 cells while keratin 19 is found in A549 cells.

Keratin 17 (D73C7) Rabbit mAb - 4543 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D73C7
Western blot analysis of extracts from A-431, HeLa, and A549 cells using Keratin 17 (D73C7) Rabbit mAb. As expected, A549 cells are negative for keratin 17.

Cytokeratin 17 (H-41) - sc-366511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cytokeratin 17 (H-41): sc-366511. Western blot analysis of Cytokeratin 17 expression in HeLa (A), A-431 (B) and T24 (C) whole cell lysates and mouse skin (D) and mouse bladder (E) tissue extracts.

Cytokeratin 17 (D-4) - sc-393091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 17 (D-4): sc-393091. Western blot analysis of Cytokeratin 17 expression in HeLa whole cell lysate.

Cytokeratin 17 (E-4) - sc-393002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 17 (E-4): sc-393002. Western blot analysis of Cytokeratin 17 expression in HeLa (A) and ME-180 (B) whole cell lysates.

Cytokeratin 17 (C-14) - sc-160054 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cytokeratin 17 (Ks17.E3) - sc-101461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Cytokeratin 17 (Ks17.E3): sc-101461. Western blot analysis of Cytokeratin 17 expression in T24 whole cell lysate.

Cytokeratin 17 (V-17) - sc-101931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
Cytokeratin 17 (V-17): sc-101931. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining.

Anti-Cytokeratin 17 antibody - ab53707 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab53707 at 1/50 dilution staining Cytokeratin 17 in human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-Cytokeratin 17 antibody - ab137846 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Cytokeratin 17 antibody (ab137846) at 1/10000 dilution + HeLa whole cell lysate at 30 µg

Anti-Cytokeratin 17 antibody - ab137865 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Cytokeratin 17 antibody (ab137865) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-Cytokeratin 17 antibody - ab195725 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cytokeratin 17 antibody (ab195725) at 1/1000 dilutionLane 1 : HeLa cell line lysatesLane 2 : A431 cell line lysatesLysates/proteins at 35 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-Cytokeratin 17 antibody - ab190739 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Cytokeratin 17 antibody (ab190739) + Hela cell extract

Anti-Cytokeratin 17 antibody - ab182602 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cytokeratin 17 antibody (ab182602) at 1/400 dilutionLane 1 : 231 cell lysateLane 2 : HeLa cell lysateLysates/proteins at 30 µg per lane.SecondaryDonkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilutiondeveloped using the ECL technique

Anti-Cytokeratin 17 antibody - ab93961 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab93961, at 1/200 dilution, staining Cytokeratin 17 in formalin-fixed, paraffin-embedded Human lung adenocarcinoma tissue by Immunohistochemistry.

Anti-Cytokeratin 17 antibody - ab55393 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Cytokeratin 17 antibody (ab55393) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-Cytokeratin 17 antibody - ab192704 from Abcam

Prices $370.00
Sizes 50 µl
Clonality Polyclonal

Anti-Cytokeratin 17 antibody - ab172017 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Cytokeratin 17 antibody (ab172017) at 1/100 dilutionLane 1 : Cytokeratin 17 transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 1/500 dilution per lane.

Anti-Cytokeratin 17 antibody [2D10] - ab125103 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2D10
All lanes : Anti-Cytokeratin 17 antibody [2D10] (ab125103) at 1/500 dilutionLane 1 : 293T cell lysate, transfected with Cytokeratin 17Lane 2 : 293T cell lysate, non-transfected

Anti-Cytokeratin 17 antibody [2D4-1G9] - ab188859 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2D4-1G9
Anti-Cytokeratin 17 antibody [2D4-1G9] (ab188859) at 1/500 dilution + Cytokeratin 17 293T cells transfected lysate

Anti-Cytokeratin 17 antibody [CK-E3] - ab49749 from Abcam

Host Mouse
Clonality Monoclonal
Clone CK-E3
ICC/IF image of ab49749 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab49749, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.
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