| Gene Symbol |
ZIC1
|
| Entrez Gene |
7545
|
| Alt Symbol |
ZIC, ZNF201
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Zic family member 1
|
| Other Description |
Zic family member 1 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 1|zinc finger protein 201|zinc finger protein ZIC 1
|
| Swissprots |
Q15915 Q2M3N1
|
| Accessions |
EAW78915 EAW78916 Q15915 BC104848 AAI04849 BC104850 AAI04851 BF920299 U79264 NM_003412 NP_003403
|
| Function |
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.
|
| Tissue Specificity |
CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. {ECO:0000269|PubMed:8542595}.
|
![Western Blot: Zic1 Overexpression Lysate (Adult Normal) [NBP2-08012] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Zic1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14524_Zic1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08012-img0001.jpg)