ZIC1

Gene Symbol ZIC1
Entrez Gene 7545
Alt Symbol ZIC, ZNF201
Species Human
Gene Type protein-coding
Description Zic family member 1
Other Description Zic family member 1 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 1|zinc finger protein 201|zinc finger protein ZIC 1
Swissprots Q15915 Q2M3N1
Accessions EAW78915 EAW78916 Q15915 BC104848 AAI04849 BC104850 AAI04851 BF920299 U79264 NM_003412 NP_003403
Function Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.
Tissue Specificity CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. {ECO:0000269|PubMed:8542595}.

Zic1 (H-50) - sc-367201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Zic1 (N-20) - sc-28148 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Zic1 (P-20) - sc-28149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zic1 (P-20): sc-28149. Western blot analysis of Zic1 expression in mouse cerebellum (A) and human cerebellum (B) tissue extracts.

Anti-Zic1 antibody - ab72694 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Zic1 antibody (ab72694) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : COLO cell extractLane 3 : Jurkat cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Zic1 antibody - ab58080 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58080 Zic1 antibody at 1ug/ml.

Anti-Zic1 antibody [EPR7291(2)] - ab134951 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7291(2)
Overlay histogram showing SH-SY5Y cells stained with ab134951 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab134951, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-ZIC / ZIC1 Antibody (aa25-42) - LS-C91430 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (Biotin) - LS-C181334 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (DY488) - LS-C181336 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (DY650) - LS-C181335 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody - LS-C150738 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (HRP) - LS-C181337 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (DY550) - LS-C181338 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (aa5-34) - LS-C326505 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (aa6-34, PE) - LS-C274053 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (aa6-34, AP) - LS-C274049 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (aa6-34, APC) - LS-C274051 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (aa6-34, FITC) - LS-C274050 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZIC / ZIC1 Antibody (clone 3F7) - LS-C198453 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F7
Detection limit for recombinant GST tagged ZIC1 is approximately 0.3 ng/ml as a capture antibody.

Anti-ZIC / ZIC1 Antibody (aa50-99) - LS-C134963 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ZIC1 antibody LS-C134963 Western blot of ACHN lysate.

Anti-ZIC / ZIC1 Antibody (Internal, clone EPR7291(2)) - LS-C154725 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7291(2)
Immunofluorescent staining of SW480 cells using anti-ZIC1 antibody.

Anti-ZIC / ZIC1 Antibody (aa6-34) - LS-C160791 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ZIC1 Antibody western blot of HL-60 cell line lysates (35 ug/lane). The ZIC1 antibody detected the ZIC1 protein (arrow).

Anti-ZIC / ZIC1 Antibody (aa1-198) - LS-C150119 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ZIC1 in Mouse Brain. ZIC1 was detected in immersion fixed frozen sections of mouse brain (cerebellum) using 15 ug/ml Goat Anti-Human/Mouse ZIC1 Antigen Affinity-purified Polyclonal Antibody overnight at 4°C. Tissue was stained with Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

ZIC1 Antibody - NB600-488 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Zic1 Antibody [NB600-488] - WB analysis of Zic1 in overexpression lysate.

ZIC1 Antibody [Unconjugated] - AF4978 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human brain tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse ZIC1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4978) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for ZIC1 at approximately 54 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
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