ZIC1
| Gene Symbol | ZIC1 |
|---|---|
| Entrez Gene | 7545 |
| Alt Symbol | ZIC, ZNF201 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Zic family member 1 |
| Other Description | Zic family member 1 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 1|zinc finger protein 201|zinc finger protein ZIC 1 |
| Swissprots | Q15915 Q2M3N1 |
| Accessions | EAW78915 EAW78916 Q15915 BC104848 AAI04849 BC104850 AAI04851 BF920299 U79264 NM_003412 NP_003403 |
| Function | Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}. |
| Tissue Specificity | CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. {ECO:0000269|PubMed:8542595}. |
Zic1 CRISPR/Cas9 KO Plasmid (h) - sc-405711 from Santa Cruz Biotechnology
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Zic1 HDR Plasmid (h) - sc-405711-HDR from Santa Cruz Biotechnology
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Zic1 Double Nickase Plasmid (h) - sc-405711-NIC from Santa Cruz Biotechnology
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Zic1 Double Nickase Plasmid (h2) - sc-405711-NIC-2 from Santa Cruz Biotechnology
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Zic1 CRISPR Activation Plasmid (h) - sc-405711-ACT from Santa Cruz Biotechnology
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Zic1 CRISPR Activation Plasmid (h2) - sc-405711-ACT-2 from Santa Cruz Biotechnology
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Zic1 Lentiviral Activation Particles (h) - sc-405711-LAC from Santa Cruz Biotechnology
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Zic1 Lentiviral Activation Particles (h2) - sc-405711-LAC-2 from Santa Cruz Biotechnology
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Zic1 siRNA (h) - sc-106710 from Santa Cruz Biotechnology
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Zic1 shRNA Plasmid (h) - sc-106710-SH from Santa Cruz Biotechnology
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Zic1 shRNA (h) Lentiviral Particles - sc-106710-V from Santa Cruz Biotechnology
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ZIC1 RNAi - H00007545-R01 from Novus Biologicals
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MISSION® esiRNA - EHU112051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23218 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23218 from Sigma-Aldrich
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ZIC1 siRNA (Human) - CRH5156 from Cohesion Biosciences
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ZIC1 - MBS8219008 from MyBioSource
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shRNA set against Human ZIC1 (NM_003412.3) - SHH452624 from Creative biogene
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shRNA set against Human ZIC1(NM_003412.3) - SHL152994 from Creative biogene
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Human ZIC1 siRNA - orb265658 from Biorbyt
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ZIC1 shRNA Plasmid (Human) - CHH5156 from Cohesion Biosciences
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ZIC1 miRNA 3'UTR clone - MiUTR1H-11452 from Creative biogene
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