ZIC1

Gene Symbol	ZIC1
Entrez Gene	7545
Alt Symbol	ZIC, ZNF201
Species	Human
Gene Type	protein-coding
Description	Zic family member 1
Other Description	Zic family member 1 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 1|zinc finger protein 201|zinc finger protein ZIC 1
Swissprots	Q15915 Q2M3N1
Accessions	EAW78915 EAW78916 Q15915 BC104848 AAI04849 BC104850 AAI04851 BF920299 U79264 NM_003412 NP_003403
Function	Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.
Tissue Specificity	CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. {ECO:0000269|PubMed:8542595}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Zic1 peptide - ab25748 from Abcam Category Peptide

Human Zic1 protein fragment - ab112375 from Abcam Category Protein Source Wheat germ Species Human

Zic1 peptide - ab201520 from Abcam Category Peptide

ZIC / ZIC1 Antibody Blocking Peptide - LS-E3851 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZIC / ZIC1 Antibody Blocking Peptide - LS-E11838 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ZIC1 Protein - H00007545-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ZIC1-Antibody-N-term-Blocking-Peptide - BP16034a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZIC1 Blocking Peptide - 33R-6832 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ZIC1 - H00007545-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ZIC1 - H00007545-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ZIC1 fusion protein - ag13400 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ZIC1 fusion protein - ag13394 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ZIC1 - ZIC1-31656TH from Creative Biomart Category Protein Source Wheat germ Species Human

Zic1/2/3 (D348) Peptide - BS2455P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Zinc finger protein ZIC 1(ZIC1) - CSB-YP618020HU CSB-EP618020HU CSB-BP618020HU CSB-MP618020HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ZIC1/2/3/4/5 Blocking Peptide - CBP4317 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken

ZIC1/2/3 Blocking Peptide - CBP4318 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken

ZIC1/2/3 Blocking Peptide - abx161529 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

ZIC1/2/3/4/5 Blocking Peptide - abx161528 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

ZIC1 (full length, N-term HIS tag) - TP760435 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Zinc finger protein ZIC 1 (ZIC1) , Recombinant Protein - MBS1316452 from MyBioSource Category Protein Prices $1,990.00, $1,990.00, $2,455.00, $2,455.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZIC1 Recombinant Protein Antigen - NBP1-86833PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZIC1 Peptide, Human - M34GP17829H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human ZIC1 Protein, His-tagged - ZIC1-440H from Creative Biomart Category Protein Source E. coli Species Human

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