| Gene Symbol |
TTI2
|
| Entrez Gene |
80185
|
| Alt Symbol |
C8orf41, MRT39
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TELO2 interacting protein 2
|
| Other Description |
TELO2-interacting protein 2|Tel2 interacting protein 2 homolog
|
| Swissprots |
Q96IM2 Q9H5N4 D3DSV7 Q6NXR4
|
| Accessions |
CAK32283 EAW63397 EAW63398 EAW63399 Q6NXR4 AI890434 AK026916 BAB15590 AK308918 AL530920 BC007387 AAH07387 BC066935 AAH66935 BX648410 DA617987 DB047280 DB112682 DB113350 JF432833 ADZ16050 XM_011544665 XP_011542967 NM_001102401 NP_001095871 NM_001265581 NP_001252510 NM_025115 NP_079391
|
| Function |
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. {ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.
|