Gene Symbol | TTI2 |
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Entrez Gene | 80185 |
Alt Symbol | C8orf41, MRT39 |
Species | Human |
Gene Type | protein-coding |
Description | TELO2 interacting protein 2 |
Other Description | TELO2-interacting protein 2|Tel2 interacting protein 2 homolog |
Swissprots | Q96IM2 Q9H5N4 D3DSV7 Q6NXR4 |
Accessions | CAK32283 EAW63397 EAW63398 EAW63399 Q6NXR4 AI890434 AK026916 BAB15590 AK308918 AL530920 BC007387 AAH07387 BC066935 AAH66935 BX648410 DA617987 DB047280 DB112682 DB113350 JF432833 ADZ16050 XM_011544665 XP_011542967 NM_001102401 NP_001095871 NM_001265581 NP_001252510 NM_025115 NP_079391 |
Function | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. {ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}. |
TTI2 CRISPR/Cas9 KO Plasmid (h) - sc-416257 from Santa Cruz Biotechnology
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TTI2 HDR Plasmid (h) - sc-416257-HDR from Santa Cruz Biotechnology
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TTI2 Double Nickase Plasmid (h) - sc-416257-NIC from Santa Cruz Biotechnology
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TTI2 Double Nickase Plasmid (h2) - sc-416257-NIC-2 from Santa Cruz Biotechnology
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TTI2 CRISPR Activation Plasmid (h) - sc-416257-ACT from Santa Cruz Biotechnology
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TTI2 CRISPR Activation Plasmid (h2) - sc-416257-ACT-2 from Santa Cruz Biotechnology
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TTI2 Lentiviral Activation Particles (h) - sc-416257-LAC from Santa Cruz Biotechnology
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TTI2 Lentiviral Activation Particles (h2) - sc-416257-LAC-2 from Santa Cruz Biotechnology
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TTI2 siRNA (h) - sc-77427 from Santa Cruz Biotechnology
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TTI2 shRNA Plasmid (h) - sc-77427-SH from Santa Cruz Biotechnology
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TTI2 shRNA (h) Lentiviral Particles - sc-77427-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5137 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5137 from Sigma-Aldrich
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TTI2 siRNA (Human) - CRJ2791 from Cohesion Biosciences
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TTI2 - MBS8203046 from MyBioSource
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shRNA set against Human C8orf41 (NM_025115.3) - SHH252657 from Creative biogene
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Human TTI2 siRNA - orb273292 from Biorbyt
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TTI2 shRNA Plasmid (Human) - CHJ2791 from Cohesion Biosciences
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TTI2 miRNA 3'UTR clone - MiUTR3H-13246 from Creative biogene
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TTI2 miRNA 3'UTR clone - MiUTR3H-13247 from Creative biogene
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