PSENEN

Gene Symbol	PSENEN
Entrez Gene	55851
Alt Symbol	MDS033, MSTP064, PEN-2, PEN2
Species	Human
Gene Type	protein-coding
Description	presenilin enhancer gamma secretase subunit
Other Description	gamma-secretase subunit PEN-2|hematopoietic stem/progenitor cells protein MDS033|presenilin enhancer 2 homolog
Swissprots	Q9NZ42 B2R5L9
Accessions	Q9NZ42 AF220053 AAF67646 AK312233 BAG35166 BC009575 AAH09575 BE563017 BQ222622 BU934029 CB136623 DQ893095 ABM84021 DQ896368 ABM87367 NM_001281532 NP_001268461 NM_172341 NP_758844
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12763021}.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Tissue Specificity	Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12110170, ECO:0000269|PubMed:12740439}.
Top Pathways	Notch signaling pathway, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PSENEN-cDNA-Clone - DC02696 from Abgent, a WuXi AppTec company Prices $136.35 Sizes 10 µg Species Human Accession BC009575

PSENEN - MBS1269114 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC009575

Human PSENEN cDNA clone(NM_172341.1) - CDFG010493 from Creative Biomart Species Human Accession NM_172341.1

Human PSENEN cDNA clone(NM_172341.1) - CDFG010495 from Creative Biomart Species Human Accession NM_172341.1

Human PSENEN ORF Clone(NM_172341.1) - CDCR321587 from Creative Biomart Species Human Accession NM_172341.1

Human PSENEN ORF Clone(NM_172341.1) - CDCR321588 from Creative Biomart Species Human Accession NM_172341.1

Human PSENEN ORF Clone(NM_172341.1) - CDCR321589 from Creative Biomart Species Human Accession NM_172341.1

Human PSENEN transcript variant 1 Gene cDNA Clone (full-length ORF Clone) - HG16270-G from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG16270-NH from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 natural ORF mammalian expression plasmid, C-HA tag - HG16270-CY from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 natural ORF mammalian expression plasmid, C-His tag - HG16270-CH from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-tagged - HG16270-NF from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG16270-NY from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 natural ORF mammalian expression plasmid, C-GFPSpark tag - HG16270-ACG from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 natural ORF mammalian expression plasmid, C-OFPSpark tag - HG16270-ACR from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 natural ORF mammalian expression plasmid - HG16270-UT from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 natural ORF mammalian expression plasmid, C-Myc tag - HG16270-CM from Sino Biological Species Human Accession NM_172341.2

Human PSENEN transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-tagged - HG16270-CF from Sino Biological Species Human Accession NM_172341.2

Human PSENEN ORF Clone(NM_172341.1) - CDCR321587 from Creative biogene Species Human

Human PSENEN ORF Clone (BC009575) - CDCS417370 from Creative biogene Species Human Accession Q9NZ42

Human PSENEN cDNA Clone(NM_172341.1) - CDFG010493 from Creative biogene Species Human

Human PSENEN cDNA Clone(NM_172341.1) - CDFG010495 from Creative biogene Species Human

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