PSENEN

Gene Symbol PSENEN
Entrez Gene 55851
Alt Symbol MDS033, MSTP064, PEN-2, PEN2
Species Human
Gene Type protein-coding
Description presenilin enhancer gamma secretase subunit
Other Description gamma-secretase subunit PEN-2|hematopoietic stem/progenitor cells protein MDS033|presenilin enhancer 2 homolog
Swissprots Q9NZ42 B2R5L9
Accessions Q9NZ42 AF220053 AAF67646 AK312233 BAG35166 BC009575 AAH09575 BE563017 BQ222622 BU934029 CB136623 DQ893095 ABM84021 DQ896368 ABM87367 NM_001281532 NP_001268461 NM_172341 NP_758844
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12763021}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Tissue Specificity Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12110170, ECO:0000269|PubMed:12740439}.
Top Pathways Notch signaling pathway, Alzheimer's disease

PEN2 (D6G8) Rabbit mAb - 8598 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6G8
Western blot analysis of extracts from various cell lines using PEN2 (D6G8) Rabbit mAb.

PEN2 (D2G6) Rabbit mAb - 8502 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2G6
Western blot analysis of extracts from various cell lines using PEN2 (D2G6) Rabbit mAb.

PEN2 Antibody - 5451 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using PEN2 Antibody.

PEN-2 (FL-101) - sc-32946 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PEN-2 (FL-101): sc-32946. Western blot analysis of PEN-2 expression in mouse placenta tissue extract.

PEN-2 (F-19) - sc-30232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PEN-2 (N-14) - sc-30231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PEN2 antibody - ab18189 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PEN2 antibody (ab18189) at 2 µg/mlLane 1 : Mouse Lung LysateLane 2 : Mouse Lung Lysate with Human PEN2 peptide (ab19147) at 1 µg/mlLysates/proteins at 20 µg per lane.SecondaryAlexa Fluor Goat polyclonal to Rabbit at 1/10000 dilutionPerformed under reducing conditions.

Anti-PEN2 antibody - ab109619 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-PEN2 antibody (ab109619) at 0.5 µg/mlLane 2 : Anti-PEN2 antibody (ab109619) at 1 µg/mlLane 1 : A20 cell lysateLane 2 : A20 cell lysate

Anti-PEN2 antibody - ab24744 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PEN2 antibody - ab57662 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57662 PEN2 antibody at 1ug/ml.

Anti-PEN2 antibody [EPR9200] - ab154830 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9200
All lanes : Anti-PEN2 antibody [EPR9200] (ab154830) at 1/1000 dilutionLane 1 : Neuro-2a cell lysate Lane 2 : Fetal lung lysateLane 3 : Human placenta lysate Lysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-PEN2 antibody - Carboxyterminal end - ab62514 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-PEN2 antibody - Carboxyterminal end (ab62514) at 0.5 µg/mlLane 2 : Anti-PEN2 antibody - Carboxyterminal end (ab62514) at 1 µg/mlLane 3 : Anti-PEN2 antibody - Carboxyterminal end (ab62514) at 2 µg/mlLane 1 : K562 cell lysateLane 2 : K562 cell lysateLane 3 : K562 cell lysateLysates/proteins at 15 µg per lane.

Anti-PSENEN / PEN-2 Antibody (N-Terminus) IHC-plus™ - LS-B3207 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PEN2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3207 concentration 5 ug/ml.

Anti-PSENEN / PEN-2 Antibody - LS-C92307 from LifeSpan Bioscience

Prices $295.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-PSENEN / PEN-2 Antibody (aa89-98, clone 12K165) - LS-C182936 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12K165

Anti-PSENEN / PEN-2 Antibody (Lys11) - LS-C191217 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PSENEN / PEN-2 Antibody - LS-C202969 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant Human PEN2 protein. Primary antibody: 2 ug/ml Rabbit Anti-PEN2 Polyclonal Antibody. The signal was developed with IRDye 800 Conjugated Goat Anti-Rabbit IgG.

Anti-PSENEN / PEN-2 Antibody (aa20-69) - LS-C145247 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PSENEN / PEN2 antibody LS-C145247 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-PSENEN / PEN-2 Antibody (C-Terminus) - LS-C135520 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PSENEN / PEN2 antibody LS-C135520 Western blot of Fetal Muscle lysate.

Anti-PSENEN / PEN-2 Antibody (aa1-50) - LS-C148699 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Presenilin enhancer protein 2 in human intestine lysate in the 1) absence and 2) presence of immunizing peptide and 3) mouse intestine lysate using LS-C148699 at 3 and 7 ug/ml, respectively. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-PSENEN / PEN-2 Antibody (C-Terminus) - LS-C19652 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of PEN2 in K562 cell lysate with PEN2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

Anti-PSENEN / PEN-2 Antibody IHC-plus™ - LS-B299 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PEN2 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B299 dilution 1:500.

Anti-PSENEN / PEN-2 Antibody (N-Terminus) - LS-C17349 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PSENEN/PEN2 Antibody - NBP2-24611 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PSENEN/PEN2 Antibody [NBP2-24611] - Analysis of Presenilin enhancer protein 2 in human intestine lysate in the 1) absence and 2) presence of immunizing peptide and 3) mouse intestine lysate using NBP2-24611. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

PSENEN/PEN2 Antibody - NB300-227 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
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