PSENEN

Gene Symbol	PSENEN
Entrez Gene	55851
Alt Symbol	MDS033, MSTP064, PEN-2, PEN2
Species	Human
Gene Type	protein-coding
Description	presenilin enhancer gamma secretase subunit
Other Description	gamma-secretase subunit PEN-2|hematopoietic stem/progenitor cells protein MDS033|presenilin enhancer 2 homolog
Swissprots	Q9NZ42 B2R5L9
Accessions	Q9NZ42 AF220053 AAF67646 AK312233 BAG35166 BC009575 AAH09575 BE563017 BQ222622 BU934029 CB136623 DQ893095 ABM84021 DQ896368 ABM87367 NM_001281532 NP_001268461 NM_172341 NP_758844
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12763021}.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Tissue Specificity	Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12110170, ECO:0000269|PubMed:12740439}.
Top Pathways	Notch signaling pathway, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PEN2 full length protein - ab132019 from Abcam Category Protein Source Wheat germ Species Human

Human PEN2 peptide - ab19147 from Abcam Category Peptide

PSENEN / PEN-2 Antibody Blocking Peptide - LS-E30286 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PSENEN / PEN-2 Antibody Blocking Peptide - LS-E30287 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PSENEN / PEN-2 Antibody Blocking Peptide - LS-E21742 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSENEN / PEN-2 Antibody Blocking Peptide - LS-E21743 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PSENEN/PEN2 Protein - H00055851-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PSENEN/PEN2 Blocking Peptide - NBP1-77268PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PSENEN/PEN2 Blocking Peptide - NBP1-77267PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PEN2-Antibody-C-term-R82-Blocking-Peptide - BP6301f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PEN2-Antibody-Center-P45-Blocking-Peptide - BP6301b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PEN2 Peptide - GTX85063-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

PEN2 Peptide - GTX85064-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Psenen Blocking Peptide - 33R-4973 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PSENEN Blocking Peptide - 33R-8714 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PEN2 - H00055851-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PEN2 - H00055851-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PEN2 Control Peptide - AP30657CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PEN2 Control Peptide - AP30658CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PEN2 Peptide - 3979P from ProSci Category Peptide Species Human

PEN2 Peptide - 3981P from ProSci Category Peptide Species Human

PSENEN fusion protein - Ag9243 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PSENEN fusion protein - Ag9067 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PSENEN, GST-tagged - PSENEN-2005H from Creative Biomart Category Protein Source E.coli Species Human

PEN2 - TP303272 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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