PSENEN

Gene Symbol PSENEN
Entrez Gene 55851
Alt Symbol MDS033, MSTP064, PEN-2, PEN2
Species Human
Gene Type protein-coding
Description presenilin enhancer gamma secretase subunit
Other Description gamma-secretase subunit PEN-2|hematopoietic stem/progenitor cells protein MDS033|presenilin enhancer 2 homolog
Swissprots Q9NZ42 B2R5L9
Accessions Q9NZ42 AF220053 AAF67646 AK312233 BAG35166 BC009575 AAH09575 BE563017 BQ222622 BU934029 CB136623 DQ893095 ABM84021 DQ896368 ABM87367 NM_001281532 NP_001268461 NM_172341 NP_758844
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12763021}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Tissue Specificity Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12110170, ECO:0000269|PubMed:12740439}.
Top Pathways Notch signaling pathway, Alzheimer's disease

PEN-2 CRISPR/Cas9 KO Plasmid (h) - sc-416265 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 HDR Plasmid (h) - sc-416265-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 Double Nickase Plasmid (h) - sc-416265-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 Double Nickase Plasmid (h2) - sc-416265-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 CRISPR Activation Plasmid (h) - sc-416265-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 CRISPR Activation Plasmid (h2) - sc-416265-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 Lentiviral Activation Particles (h) - sc-416265-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 Lentiviral Activation Particles (h2) - sc-416265-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PEN-2 siRNA (h) - sc-45986 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PEN-2 shRNA Plasmid (h) - sc-45986-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PEN-2 shRNA (h) Lentiviral Particles - sc-45986-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSENEN/PEN2 RNAi - H00055851-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU220611 from Sigma-Aldrich

Category siRNA
Prices $140.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17571 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17571 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00639 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00639

PSENEN siRNA (Human) - CRJ0971 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PSENEN (NM_172341.1) - SHH384884 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PSENEN(NM_172341.1) - SHR146104 from Creative biogene

Category siRNA
Species Reactivities Human

PSENEN shRNA Plasmid (Human) - CHJ0971 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PSENEN miRNA 3'UTR clone - MiUTR1H-08363 from Creative biogene

Species Reactivities Human
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