ARHGEF25

Gene Symbol ARHGEF25
Entrez Gene 115557
Alt Symbol GEFT, p63RhoGEF
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 25
Other Description RAC/CDC42 exchange factor|RhoA/RAC/CDC42 exchange factor|guanine nucleotide exchange factor GEFT|rac/Cdc42/Rho exchange factor GEFT|rho guanine nucleotide exchange factor 25|rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
Swissprots Q96E63 A9CQZ6 A6NJH5 Q8WV84 F8W7Z4 Q86VW2
Accessions Q86VW2 AB370196 BAF94999 AF487514 AAO49463 AI677902 BC012860 AAH12860 BC018536 AAH18536 BC047559 AAH47559 DB481981 NM_133483 NM_001111270 NP_001104740 NM_182947 NP_891992 NR_046223
Function May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11861769}. Note=Highly colocalizes with actin regions.
Tissue Specificity Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver. {ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594}.

GEFT (G-14) - sc-161637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GEFT (G-14): sc-161637. Western blot analysis of GEFT expression in mouse skeletal muscle tissue extract.

GEFT (H-63) - sc-366904 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GEFT (S-16) - sc-161639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GEFT antibody - ab127690 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-GEFT antibody (ab127690) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

Anti-GEFT antibody - ab81684 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GEFT antibody (ab81684) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG should be diluted 1/50,000 - 1/100,000 as secondary antibody.

Anti-ARHGEF25 / GEFT Antibody (aa506-555) - LS-C82758 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-ARHGEF25 / GEFT Antibody - LS-C155646 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Breast ca, using GEFT antibody at 1:250 dilution.

GEFT Antibody - NBP2-16636 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GEFT Antibody [NBP2-16636] - Sample (30 ug of whole cell lysate) A: IMR32 10% SDS PAGE gel, diluted at 1:1000.

GEFT Antibody - NBP1-54351 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: GEFT Antibody [NBP1-54351] - Titration: 0.2-1 ug/ml, Positive Control: Human brain.

GEFT Antibody - NBP2-14309 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: GEFT Antibody [NBP2-14309] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

GEFT Polyclonal Antibody - bs-11844R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11844R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11844R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11844R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11844R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, Cy3 Conjugated - bs-11844R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, Cy5 Conjugated - bs-11844R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, Cy5.5 Conjugated - bs-11844R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, Cy7 Conjugated - bs-11844R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, FITC Conjugated - bs-11844R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, Biotin Conjugated - bs-11844R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GEFT Polyclonal Antibody, HRP Conjugated - bs-11844R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF25 antibody produced in rabbit - HPA052016 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ARHGEF25:<B>Cat. No. HPA052016</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

Anti-ARHGEF25 antibody produced in rabbit - SAB2701512 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ARHGEF25: <B>Cat. No. SAB2701512</B>: Immunohistochemical analysis of paraffin-embedded Breast carcinoma, using GEFT antibody at 1:500 dilution.

Anti-GEFT antibody produced in rabbit - SAB2100911 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-GEFT: <B>Cat. No.SAB2100911</B>: GEFT in Fetal Brain tissue lysate with GEFT antibody at 1.0 μg/mL.
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