| Gene Symbol |
ARHGEF25
|
| Entrez Gene |
115557
|
| Alt Symbol |
GEFT, p63RhoGEF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho guanine nucleotide exchange factor (GEF) 25
|
| Other Description |
RAC/CDC42 exchange factor|RhoA/RAC/CDC42 exchange factor|guanine nucleotide exchange factor GEFT|rac/Cdc42/Rho exchange factor GEFT|rho guanine nucleotide exchange factor 25|rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
|
| Swissprots |
Q96E63 A9CQZ6 A6NJH5 Q8WV84 F8W7Z4 Q86VW2
|
| Accessions |
Q86VW2 AB370196 BAF94999 AF487514 AAO49463 AI677902 BC012860 AAH12860 BC018536 AAH18536 BC047559 AAH47559 DB481981 NM_133483 NM_001111270 NP_001104740 NM_182947 NP_891992 NR_046223
|
| Function |
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11861769}. Note=Highly colocalizes with actin regions.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver. {ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594}.
|