ARHGEF25

Gene Symbol ARHGEF25
Entrez Gene 115557
Alt Symbol GEFT, p63RhoGEF
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 25
Other Description RAC/CDC42 exchange factor|RhoA/RAC/CDC42 exchange factor|guanine nucleotide exchange factor GEFT|rac/Cdc42/Rho exchange factor GEFT|rho guanine nucleotide exchange factor 25|rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
Swissprots Q96E63 A9CQZ6 A6NJH5 Q8WV84 F8W7Z4 Q86VW2
Accessions Q86VW2 AB370196 BAF94999 AF487514 AAO49463 AI677902 BC012860 AAH12860 BC018536 AAH18536 BC047559 AAH47559 DB481981 NM_133483 NM_001111270 NP_001104740 NM_182947 NP_891992 NR_046223
Function May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11861769}. Note=Highly colocalizes with actin regions.
Tissue Specificity Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver. {ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594}.

ARHGEF25 / GEFT Antibody Blocking Peptide - LS-E19299 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

GEFT Blocking Peptide - 33R-8023 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

GEFT fusion protein - ag10436 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

GEFT fusion protein - Ag10819 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human ARHGEF25 - ARHGEF25-975H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human GEFT, His-tagged - GEFT-13220H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Rho guanine nucleotide exchange factor 25(ARHGEF25) - CSB-YP803131HU CSB-EP803131HU CSB-BP803131HU CSB-MP803131HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

GEFT Recombinant Protein Antigen - NBP2-14309PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

GEFT-Antibody-Center-Blocking-Peptide - BP9782c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

ARHGEF25 Peptide, Human - M34GP00889H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Rho guanine nucleotide exchange factor 25 (ARHGEF25), Recombinant Protein - MBS1369997 from MyBioSource

Category Protein
Prices $1,380.00, $1,380.00, $1,600.00, $1,600.00, $2,300.00, $2,300.00, $2,740.00, $2,740.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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