ARHGEF25

Gene Symbol ARHGEF25
Entrez Gene 115557
Alt Symbol GEFT, p63RhoGEF
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 25
Other Description RAC/CDC42 exchange factor|RhoA/RAC/CDC42 exchange factor|guanine nucleotide exchange factor GEFT|rac/Cdc42/Rho exchange factor GEFT|rho guanine nucleotide exchange factor 25|rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
Swissprots Q96E63 A9CQZ6 A6NJH5 Q8WV84 F8W7Z4 Q86VW2
Accessions Q86VW2 AB370196 BAF94999 AF487514 AAO49463 AI677902 BC012860 AAH12860 BC018536 AAH18536 BC047559 AAH47559 DB481981 NM_133483 NM_001111270 NP_001104740 NM_182947 NP_891992 NR_046223
Function May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11861769}. Note=Highly colocalizes with actin regions.
Tissue Specificity Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver. {ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594}.

GEFT CRISPR/Cas9 KO Plasmid (h) - sc-406707 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT HDR Plasmid (h) - sc-406707-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT Double Nickase Plasmid (h) - sc-406707-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT Double Nickase Plasmid (h2) - sc-406707-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT CRISPR Activation Plasmid (h) - sc-406707-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT CRISPR Activation Plasmid (h2) - sc-406707-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT Lentiviral Activation Particles (h) - sc-406707-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT Lentiviral Activation Particles (h2) - sc-406707-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT siRNA (h) - sc-95849 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GEFT shRNA Plasmid (h) - sc-95849-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GEFT shRNA (h) Lentiviral Particles - sc-95849-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU230971 from Sigma-Aldrich

Category siRNA
Prices $140.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3452 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3452 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02732 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02732

ARHGEF25 siRNA (Human) - CRJ4452 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARHGEF25 - MBS8202398 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ARHGEF25 (NM_182947.3) - SHH239794 from Creative biogene

Category siRNA
Species Reactivities Human

GEFT CRISPR/Cas9 KO Plasmid (h2) - sc-406707-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GEFT HDR Plasmid (h2) - sc-406707-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGEF25 shRNA Plasmid (Human) - CHJ4452 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ARHGEF25 miRNA 3'UTR clone - MiUTR3H-11087 from Creative biogene

Species Reactivities Human

ARHGEF25 miRNA 3'UTR clone - MiUTR3H-11088 from Creative biogene

Species Reactivities Human
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