| Gene Symbol |
ZNF385A
|
| Entrez Gene |
25946
|
| Alt Symbol |
HZF, RZF, ZFP385, ZNF385
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 385A
|
| Other Description |
hematopoietic zinc finger protein|retinal zinc finger protein|zinc finger protein 385
|
| Swissprots |
F1T0F1 J3KNS3 B2RDN5 Q5VH53 B4DKH2 Q9H7R6 Q96PM9 Q9UFU3
|
| Accessions |
EAW96777 EAW96778 EAW96779 Q96PM9 AB593085 BAJ84025 AF304052 AAL08625 AK024404 BAB14910 AK092724 AK296564 BAG59184 AK315613 BAG37982 AL117462 CAB55938 AY461717 AAS19275 BC029752 AAH29752 BM476090 BM546460 BP305142 CR457327 CAG33608 DB116264 DB169664 XM_005268783 XP_005268840 XM_006719342 XP_006719405 XM_011538168 XP_011536470 XM_011538169 XP_011536471 XM_011538170 XP_011536472 XM_011538171 XP_011536473 NM_001130967 NP_001124439 NM_001130968 NP_001124440 NM_001290001 NP_001276930 NM_001290002 NP_001276931 NM_001290004 NP_001276933 NM_015481 NP_056296
|
| Function |
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti- proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {E
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15527981}. Nucleus, nucleolus {ECO:0000269|PubMed:15527981}. Cell projection, dendrite {ECO:0000250}. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}.
|
| Tissue Specificity |
Expressed predominantly in the retina. {ECO:0000269|PubMed:15527981}.
|