Gene Symbol | ZNF385A |
---|---|
Entrez Gene | 25946 |
Alt Symbol | HZF, RZF, ZFP385, ZNF385 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger protein 385A |
Other Description | hematopoietic zinc finger protein|retinal zinc finger protein|zinc finger protein 385 |
Swissprots | F1T0F1 J3KNS3 B2RDN5 Q5VH53 B4DKH2 Q9H7R6 Q96PM9 Q9UFU3 |
Accessions | EAW96777 EAW96778 EAW96779 Q96PM9 AB593085 BAJ84025 AF304052 AAL08625 AK024404 BAB14910 AK092724 AK296564 BAG59184 AK315613 BAG37982 AL117462 CAB55938 AY461717 AAS19275 BC029752 AAH29752 BM476090 BM546460 BP305142 CR457327 CAG33608 DB116264 DB169664 XM_005268783 XP_005268840 XM_006719342 XP_006719405 XM_011538168 XP_011536470 XM_011538169 XP_011536471 XM_011538170 XP_011536472 XM_011538171 XP_011536473 NM_001130967 NP_001124439 NM_001130968 NP_001124440 NM_001290001 NP_001276930 NM_001290002 NP_001276931 NM_001290004 NP_001276933 NM_015481 NP_056296 |
Function | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti- proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {E |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15527981}. Nucleus, nucleolus {ECO:0000269|PubMed:15527981}. Cell projection, dendrite {ECO:0000250}. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}. |
Tissue Specificity | Expressed predominantly in the retina. {ECO:0000269|PubMed:15527981}. |
ZNF385A (H-97) - sc-292258 from Santa Cruz Biotechnology
|
||||||||
ZNF385A (T-14) - sc-132537 from Santa Cruz Biotechnology
|
||||||||
ZNF385A (Q-23) - sc-102213 from Santa Cruz Biotechnology
|
||||||||
Anti-ZNF385 antibody - ab190111 from Abcam
|
||||||||
Anti-ZNF385 antibody - ab169007 from Abcam
|
||||||||
Anti-ZNF385 antibody - ab42458 from Abcam
|
||||||||
Anti-ZNF385 antibody - N-terminal - ab173507 from Abcam
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa56-83, AP) - LS-C243174 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa56-83, APC) - LS-C243175 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa56-83, Biotin) - LS-C243176 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa56-83, FITC) - LS-C243177 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa56-83, PE) - LS-C243178 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa56-83, Azide-free, HRP) - LS-C247338 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa56-83) - LS-C326594 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa57-83) - LS-C157450 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (aa256-305) - LS-C29762 from LifeSpan Bioscience
|
||||||||
Anti-ZNF385A / ZNF385 Antibody (N-Terminus) IHC-plus⢠- LS-B8062 from LifeSpan Bioscience
|
||||||||
ZNF385 Antibody - NBP1-80004 from Novus Biologicals
|
||||||||
ZNF385 Antibody - NBP1-79983 from Novus Biologicals
|
||||||||
ZNF385 Antibody - NBP1-85070 from Novus Biologicals
|
||||||||
ZNF385 Antibody - H00025946-B01P from Novus Biologicals
|
||||||||
Anti-ZNF385 (AB1) antibody produced in rabbit - AV31849 from Sigma-Aldrich
|
||||||||
Anti-ZNF385 antibody produced in mouse - SAB1409083 from Sigma-Aldrich
|
||||||||
Anti-ZNF385 (AB2) antibody produced in rabbit - AV32542 from Sigma-Aldrich
|
||||||||
ANTI-ZNF385A(N-TERMINAL) antibody produced in rabbit - SAB1305156 from Sigma-Aldrich
|