Gene Symbol | ZNF385A |
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Entrez Gene | 25946 |
Alt Symbol | HZF, RZF, ZFP385, ZNF385 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger protein 385A |
Other Description | hematopoietic zinc finger protein|retinal zinc finger protein|zinc finger protein 385 |
Swissprots | F1T0F1 J3KNS3 B2RDN5 Q5VH53 B4DKH2 Q9H7R6 Q96PM9 Q9UFU3 |
Accessions | EAW96777 EAW96778 EAW96779 Q96PM9 AB593085 BAJ84025 AF304052 AAL08625 AK024404 BAB14910 AK092724 AK296564 BAG59184 AK315613 BAG37982 AL117462 CAB55938 AY461717 AAS19275 BC029752 AAH29752 BM476090 BM546460 BP305142 CR457327 CAG33608 DB116264 DB169664 XM_005268783 XP_005268840 XM_006719342 XP_006719405 XM_011538168 XP_011536470 XM_011538169 XP_011536471 XM_011538170 XP_011536472 XM_011538171 XP_011536473 NM_001130967 NP_001124439 NM_001130968 NP_001124440 NM_001290001 NP_001276930 NM_001290002 NP_001276931 NM_001290004 NP_001276933 NM_015481 NP_056296 |
Function | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti- proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {E |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15527981}. Nucleus, nucleolus {ECO:0000269|PubMed:15527981}. Cell projection, dendrite {ECO:0000250}. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}. |
Tissue Specificity | Expressed predominantly in the retina. {ECO:0000269|PubMed:15527981}. |
Human ZNF385 full length protein - ab161842 from Abcam
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Human ZNF385 protein fragment - ab161843 from Abcam
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ZNF385A / ZNF385 Antibody Blocking Peptide - LS-E5331 from LifeSpan Bioscience
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ZNF385A / ZNF385 Antibody Blocking Peptide - LS-E11420 from LifeSpan Bioscience
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ZNF385A / ZNF385 Antibody Blocking Peptide - LS-E11106 from LifeSpan Bioscience
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Recombinant Human ZNF385 Protein - H00025946-P01 from Novus Biologicals
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Recombinant Human ZNF385 Protein - H00025946-Q01 from Novus Biologicals
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ZNF385A-Antibody-N-term-Blocking-Peptide - BP17816a from Abgent, a WuXi AppTec company
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RNF39/LIRF blocking peptide - GTX89713-PEP from GeneTex
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ZNF385 Blocking Peptide - 33R-2624 from Fitzgerald
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ZNF385 Blocking Peptide - 33R-5098 from Fitzgerald
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ZNF385A - H00025946-P01-10 from Acris Antibodies
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ZNF385A - H00025946-P01-25 from Acris Antibodies
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ZNF385A - H00025946-Q01-10 from Acris Antibodies
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ZNF385A - H00025946-Q01-25 from Acris Antibodies
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Recombinant Ring Finger Protein 39 (RNF39) - RPE945Hu01 from Cloud-clone
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Recombinant Human Zinc finger protein 385A(ZNF385A) - CSB-YP026710HU CSB-EP026710HU CSB-BP026710HU CSB-MP026710HU from Cusabio
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ZNF385A fusion protein - Ag23577 from Proteintech Group
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ZNF385A (transcript variant 3) - TP304379 from Acris Antibodies
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Zinc finger protein 385A (ZNF385A) , Recombinant Protein - MBS1352632 from MyBioSource
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ZNF385 Recombinant Protein Antigen - NBP1-85070PEP from Novus Biologicals
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ZNF385A Peptide, Human - M34GP18021H from Creative Peptides
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