| Gene Symbol |
FHOD1
|
| Entrez Gene |
29109
|
| Alt Symbol |
FHOS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
formin homology 2 domain containing 1
|
| Other Description |
FH1/FH2 domain-containing protein 1|formin homolog overexpressed in spleen 1
|
| Swissprots |
Q9Y613 Q8N521 Q6Y1F2 Q76MS8 Q59F76
|
| Accessions |
EAW83109 EAW83110 EAW83111 EAW83112 EAW83113 Q9Y613 AA609867 AB041046 BAD06250 AB209584 BAD92821 AF113615 AAD39906 AK025992 AK301157 BAG62747 AK304232 BAG65101 AY192154 AAO38757 BC033084 AAH33084 CN302043 KJ658417 AID62088 XM_005255909 XP_005255966 XM_005255910 XP_005255967 XM_006721180 XP_006721243 XM_011523043 XP_011521345 XM_011523044 XP_011521346 XM_011523045 XP_011521347 XR_933285 XR_933286 NM_013241 NP_037373
|
| Function |
Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in spleen.
|