Gene Symbol | FHOD1 |
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Entrez Gene | 29109 |
Alt Symbol | FHOS |
Species | Human |
Gene Type | protein-coding |
Description | formin homology 2 domain containing 1 |
Other Description | FH1/FH2 domain-containing protein 1|formin homolog overexpressed in spleen 1 |
Swissprots | Q9Y613 Q8N521 Q6Y1F2 Q76MS8 Q59F76 |
Accessions | EAW83109 EAW83110 EAW83111 EAW83112 EAW83113 Q9Y613 AA609867 AB041046 BAD06250 AB209584 BAD92821 AF113615 AAD39906 AK025992 AK301157 BAG62747 AK304232 BAG65101 AY192154 AAO38757 BC033084 AAH33084 CN302043 KJ658417 AID62088 XM_005255909 XP_005255966 XM_005255910 XP_005255967 XM_006721180 XP_006721243 XM_011523043 XP_011521345 XM_011523044 XP_011521346 XM_011523045 XP_011521347 XR_933285 XR_933286 NM_013241 NP_037373 |
Function | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic. |
Tissue Specificity | Ubiquitous. Highly expressed in spleen. |
FHOD1 CRISPR/Cas9 KO Plasmid (h) - sc-404286 from Santa Cruz Biotechnology
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FHOD1 HDR Plasmid (h) - sc-404286-HDR from Santa Cruz Biotechnology
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FHOD1 Double Nickase Plasmid (h) - sc-404286-NIC from Santa Cruz Biotechnology
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FHOD1 Double Nickase Plasmid (h2) - sc-404286-NIC-2 from Santa Cruz Biotechnology
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FHOD1 CRISPR Activation Plasmid (h) - sc-404286-ACT from Santa Cruz Biotechnology
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FHOD1 CRISPR Activation Plasmid (h2) - sc-404286-ACT-2 from Santa Cruz Biotechnology
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FHOD1 Lentiviral Activation Particles (h) - sc-404286-LAC from Santa Cruz Biotechnology
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FHOD1 Lentiviral Activation Particles (h2) - sc-404286-LAC-2 from Santa Cruz Biotechnology
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FHOD1 siRNA (h) - sc-60635 from Santa Cruz Biotechnology
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FHOD1 shRNA Plasmid (h) - sc-60635-SH from Santa Cruz Biotechnology
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FHOD1 shRNA (h) Lentiviral Particles - sc-60635-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8686 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8686 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00915 from Sigma-Aldrich
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FHOD1 siRNA (Human) - CRH9200 from Cohesion Biosciences
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FHOD1 - MBS8228845 from MyBioSource
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shRNA set against Human FHOD1 (NM_013241.2) - SHH294909 from Creative biogene
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Human FHOD1 siRNA - orb269702 from Biorbyt
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FHOD1 shRNA Plasmid (Human) - CHH9200 from Cohesion Biosciences
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FHOD1 miRNA 3'UTR clone - MiUTR1H-03653 from Creative biogene
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