| Gene Symbol |
BRD4
|
| Entrez Gene |
23476
|
| Alt Symbol |
CAP, HUNK1, HUNKI, MCAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bromodomain containing 4
|
| Other Description |
bromodomain-containing 4|bromodomain-containing protein 4|chromosome-associated protein
|
| Swissprots |
Q4G0X8 O60885 O60433 Q96PD3
|
| Accessions |
AAC27978 EAW84469 EAW84470 EAW84471 EAW84472 EAW84473 O60885 AF252390 AF386649 AAL26987 AK307664 BC000156 AAH00156 BC008354 AAH08354 BC030158 AAH30158 BC035266 AAH35266 BC038988 AAH38988 BC047888 AAH47888 BC067129 AAH67129 BC091649 AAH91649 DQ580084 KF974357 AHK61044 Y12059 CAA72780 XM_011527854 XP_011526156 XM_011527855 XP_011526157 XM_011527856 XP_011526158 NM_014299 NP_055114 NM_058243 NP_490597
|
| Function |
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P- TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P- TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical
|
| Subcellular Location |
Nucleus. Chromosome. Note=Associates with acetylated chromatin. Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:12543779}.
|