BRD4

Gene Symbol	BRD4
Entrez Gene	23476
Alt Symbol	CAP, HUNK1, HUNKI, MCAP
Species	Human
Gene Type	protein-coding
Description	bromodomain containing 4
Other Description	bromodomain-containing 4|bromodomain-containing protein 4|chromosome-associated protein
Swissprots	Q4G0X8 O60885 O60433 Q96PD3
Accessions	AAC27978 EAW84469 EAW84470 EAW84471 EAW84472 EAW84473 O60885 AF252390 AF386649 AAL26987 AK307664 BC000156 AAH00156 BC008354 AAH08354 BC030158 AAH30158 BC035266 AAH35266 BC038988 AAH38988 BC047888 AAH47888 BC067129 AAH67129 BC091649 AAH91649 DQ580084 KF974357 AHK61044 Y12059 CAA72780 XM_011527854 XP_011526156 XM_011527855 XP_011526157 XM_011527856 XP_011526158 NM_014299 NP_055114 NM_058243 NP_490597
Function	Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P- TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P- TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical
Subcellular Location	Nucleus. Chromosome. Note=Associates with acetylated chromatin. Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:12543779}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Brd4 peptide - ab85811 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Brd4 protein fragment - ab176936 from Abcam Category Protein Prices $285.00 Sizes 20 µg Source E. coli Species Human

Human Brd4 protein fragment - ab176941 from Abcam Category Protein Prices $293.00 Sizes 20 µg Source E. coli Species Human

BRD4 Antibody Blocking Peptide - LS-E4778 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRD4 Antibody Blocking Peptide - LS-E14091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRD4 Antibody Blocking Peptide - LS-E14092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRD4-Antibody-C-term-Blocking-Peptide - BP17153b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BRD4 Blocking Peptide - 33R-2467 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BRD4 fusion protein - Ag20736 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant BRD4 (44-168) protein - 31380 from ActiveMotif Category Protein Prices $395.00, $2,600.00 Sizes 100 µg, 1 mg Source E. coli Species Human

Recombinant BRD4 (333-460) protein - 31446 from ActiveMotif Category Protein Prices $395.00, $2,600.00 Sizes 100 μg, 1 mg Source E. coli Species Human

Recombinant Human BRD4, GST-tagged - BRD4-1904H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BRD4, GST-tagged - BRD4-1905H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BRD4, His-tagged - BRD4-1918H from Creative Biomart Category Protein Source Human 293 cell Species Human

Recombinant Human BRD4, His-tagged - BRD4-1919H from Creative Biomart Category Protein Source Human 293 cell Species Human

Recombinant Human BRD4, His-tagged - BRD4-1920H from Creative Biomart Category Protein Source Human 293 cell Species Human

Recombinant Human BRD4, His-tagged - BRD4-1921H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BRD4, His-tagged - BRD4-1922H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BRD4, His-tagged - BRD4-1923H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BRD4, GST-tagged - BRD4-158H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BRD4, His&FLAG-tagged - BRD4-36H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human BRD4 - BRD4-902H from Creative Biomart Category Protein Source Mammalian Cells Species Human

BRDT (22-138aa), His, Human - Z03188-100 from GenScript Category Protein Prices $195.00 Sizes 100 μg Source E. coli Species Human

BRD4 (49-460aa), His, Human - Z03187-100 from GenScript Category Protein Prices $195.00 Sizes 100 μg Source E. coli Species Human

Recombinant Human Bromodomain-containing protein 4(BRD4) ,partial - CSB-YP002802HU CSB-EP002802HU CSB-BP002802HU CSB-MP002802HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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