| Gene Symbol |
AADAC
|
| Entrez Gene |
13
|
| Alt Symbol |
CES5A1, DAC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
arylacetamide deacetylase
|
| Other Description |
arylacetamide deacetylase (esterase)
|
| Swissprots |
P22760 Q8N1A9 D3DNJ6 A8K3L3
|
| Accessions |
EAW78791 EAW78792 P22760 AK290628 BAF83317 AV705031 BC020706 BC032309 AAH32309 L32179 AAA35551 XM_005247104 XP_005247161 NM_001086 NP_001077
|
| Function |
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269|PubMed:17936933, ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931, ECO:0000269|PubMed:23542347}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder. {ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931}.
|
![Western Blot: AADAC Overexpression Lysate (Adult Normal) [NBL1-07161] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AADAC.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/899_AADAC%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07161-img0002.jpg)