Gene Symbol | AADAC |
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Entrez Gene | 13 |
Alt Symbol | CES5A1, DAC |
Species | Human |
Gene Type | protein-coding |
Description | arylacetamide deacetylase |
Other Description | arylacetamide deacetylase (esterase) |
Swissprots | P22760 Q8N1A9 D3DNJ6 A8K3L3 |
Accessions | EAW78791 EAW78792 P22760 AK290628 BAF83317 AV705031 BC020706 BC032309 AAH32309 L32179 AAA35551 XM_005247104 XP_005247161 NM_001086 NP_001077 |
Function | Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269|PubMed:17936933, ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931, ECO:0000269|PubMed:23542347}. |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein. |
Tissue Specificity | Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder. {ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931}. |
AADAC (G-12) - sc-390591 from Santa Cruz Biotechnology
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AADAC (H-8) - sc-390592 from Santa Cruz Biotechnology
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AADAC (K-14) - sc-99249 from Santa Cruz Biotechnology
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Anti-AADAC antibody - ab101144 from Abcam
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Anti-AADAC antibody - ab62176 from Abcam
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Anti-AADAC antibody - ab54694 from Abcam
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Anti-AADAC Antibody - LS-C137353 from LifeSpan Bioscience
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Anti-AADAC Antibody (clone 2E8) - LS-C196590 from LifeSpan Bioscience
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Anti-AADAC Antibody (aa301-350) - LS-C40510 from LifeSpan Bioscience
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Anti-AADAC Antibody (aa38-87) - LS-C80688 from LifeSpan Bioscience
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Anti-AADAC Antibody (aa273-300) - LS-C155827 from LifeSpan Bioscience
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AADAC Antibody - NBP1-85680 from Novus Biologicals
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AADAC Antibody - NBP1-62428 from Novus Biologicals
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AADAC Antibody (2E8.) - H00000013-M01 from Novus Biologicals
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AADAC Antibody - NBP1-69445 from Novus Biologicals
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AADAC Antibody - NBP1-31936 from Novus Biologicals
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AADAC Antibody - H00000013-A01 from Novus Biologicals
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Anti-AADAC antibody produced in rabbit - SAB2100004 from Sigma-Aldrich
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Monoclonal Anti-AADAC antibody produced in mouse - WH0000013M1 from Sigma-Aldrich
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Anti-AADAC antibody produced in rabbit - HPA002911 from Sigma-Aldrich
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Anti-AADAC antibody produced in rabbit - AV45038 from Sigma-Aldrich
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AADAC antibody - N-terminal region (ARP45036_P050) - ARP45036_P050 from Aviva Systems Biology
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AADAC antibody - C-terminal region (ARP45038_T100) - ARP45038_T100 from Aviva Systems Biology
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AADAC-Antibody-C-term - AP6805b from Abgent, a WuXi AppTec company
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AADAC-Antibody-monoclonal-M01 - AT1002a from Abgent, a WuXi AppTec company
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