Gene Symbol | AADAC |
---|---|
Entrez Gene | 13 |
Alt Symbol | CES5A1, DAC |
Species | Human |
Gene Type | protein-coding |
Description | arylacetamide deacetylase |
Other Description | arylacetamide deacetylase (esterase) |
Swissprots | P22760 Q8N1A9 D3DNJ6 A8K3L3 |
Accessions | EAW78791 EAW78792 P22760 AK290628 BAF83317 AV705031 BC020706 BC032309 AAH32309 L32179 AAA35551 XM_005247104 XP_005247161 NM_001086 NP_001077 |
Function | Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269|PubMed:17936933, ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931, ECO:0000269|PubMed:23542347}. |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein. |
Tissue Specificity | Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder. {ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931}. |