Gene Symbol | ESYT1 |
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Entrez Gene | 23344 |
Alt Symbol | FAM62A, MBC2 |
Species | Human |
Gene Type | protein-coding |
Description | extended synaptotagmin-like protein 1 |
Other Description | extended synaptotagmin-1|family with sequence similarity 62 (C2 domain containing), member A|membrane-bound C2 domain-containing protein |
Swissprots | Q9BSJ8 A0FGR7 Q9Y416 Q9H6W2 A8K2S2 O94848 Q6PJN4 Q9H6J1 |
Accessions | EAW96890 EAW96891 EAW96892 EAW96893 Q9BSJ8 AB018290 BAA34467 AJ346011 AK022790 BAG51117 AK025463 BAB15139 AK025878 BAB15268 AK074368 AK128730 BAG54718 AK225035 AK290337 BAF83026 AL050134 CAB43284 BC004998 AAH04998 BC013880 DB100366 DQ993200 ABJ97705 EU832620 ACE87711 EU832692 ACE87024 NM_001184796 NP_001171725 NM_015292 NP_056107 |
Function | Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667}. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:17360437}. |
ESYT1 Antibody Blocking Peptide - LS-E4513 from LifeSpan Bioscience
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ESYT1 Antibody Blocking Peptide - LS-E26608 from LifeSpan Bioscience
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ESYT1 Antibody Blocking Peptide - LS-E29680 from LifeSpan Bioscience
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ESYT1 Antibody Blocking Peptide - LS-E29681 from LifeSpan Bioscience
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ESYT1 Antibody Blocking Peptide - LS-E29682 from LifeSpan Bioscience
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ESYT1 Antibody Blocking Peptide - LS-E29683 from LifeSpan Bioscience
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ESYT1-Antibody-C-term-Blocking-Peptide - BP16840b from Abgent, a WuXi AppTec company
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FAM62A blocking peptide - GTX88786-PEP from GeneTex
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Human MBC2 protein - orb245109 from Biorbyt
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FAM62A Peptide - AC21-1444-P from Abcore
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FAM62A Peptide - 46-657P from ProSci
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FAM62A fusion protein - ag13895 from Proteintech Group
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Recombinant human Extended synaptotagmin-1 - CSB-EP020054h(B) CSB-BP020054h(B) CSB-MP020054h(B) from Cusabio
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Recombinant human Zinc finger protein 91 - CSB-EP020054h(A) CSB-BP020054h(A) CSB-MP020054h(A) from Cusabio
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Recombinant Human Extended synaptotagmin-1(MBC2),partial - CSB-RP020054h(B) from Cusabio
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Recombinant Human Zinc finger protein 91(ZNF91),partial - CSB-RP020054h(A) from Cusabio
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Extended synaptotagmin-1 - RPC140517 from Biomatik
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ESYT1 - TP301380 from Acris Antibodies
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FAM62A, Peptide - MBS426100 from MyBioSource
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FAM62A, Peptide - MBS658306 from MyBioSource
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FAM62A Recombinant Protein Antigen - NBP1-84741PEP from Novus Biologicals
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Recombinant human Extended synaptotagmin-1 (OPCA00427) - OPCA00427 from Aviva Systems Biology
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ESYT1 Peptide, Human - M34GP05090H from Creative Peptides
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ZNF91 Recombinant Protein (OPCA02571) - OPCA02571 from Aviva Systems Biology
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MBC2 Recombinant Protein (OPCA02572) - OPCA02572 from Aviva Systems Biology
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