Gene Symbol | ESYT1 |
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Entrez Gene | 23344 |
Alt Symbol | FAM62A, MBC2 |
Species | Human |
Gene Type | protein-coding |
Description | extended synaptotagmin-like protein 1 |
Other Description | extended synaptotagmin-1|family with sequence similarity 62 (C2 domain containing), member A|membrane-bound C2 domain-containing protein |
Swissprots | Q9BSJ8 A0FGR7 Q9Y416 Q9H6W2 A8K2S2 O94848 Q6PJN4 Q9H6J1 |
Accessions | EAW96890 EAW96891 EAW96892 EAW96893 Q9BSJ8 AB018290 BAA34467 AJ346011 AK022790 BAG51117 AK025463 BAB15139 AK025878 BAB15268 AK074368 AK128730 BAG54718 AK225035 AK290337 BAF83026 AL050134 CAB43284 BC004998 AAH04998 BC013880 DB100366 DQ993200 ABJ97705 EU832620 ACE87711 EU832692 ACE87024 NM_001184796 NP_001171725 NM_015292 NP_056107 |
Function | Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667}. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:17360437}. |
MISSION® esiRNA - EHU041551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7996 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7996 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07085 from Sigma-Aldrich
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ESYT1 siRNA (Human) - CRH8195 from Cohesion Biosciences
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FAM62A CRISPR/Cas9 KO Plasmid (h) - sc-416433 from Santa Cruz Biotechnology
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FAM62A HDR Plasmid (h) - sc-416433-HDR from Santa Cruz Biotechnology
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FAM62A Double Nickase Plasmid (h) - sc-416433-NIC from Santa Cruz Biotechnology
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FAM62A Double Nickase Plasmid (h2) - sc-416433-NIC-2 from Santa Cruz Biotechnology
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FAM62A CRISPR Activation Plasmid (h) - sc-416433-ACT from Santa Cruz Biotechnology
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FAM62A CRISPR Activation Plasmid (h2) - sc-416433-ACT-2 from Santa Cruz Biotechnology
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FAM62A Lentiviral Activation Particles (h) - sc-416433-LAC from Santa Cruz Biotechnology
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FAM62A Lentiviral Activation Particles (h2) - sc-416433-LAC-2 from Santa Cruz Biotechnology
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FAM62A siRNA (h) - sc-95714 from Santa Cruz Biotechnology
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FAM62A shRNA Plasmid (h) - sc-95714-SH from Santa Cruz Biotechnology
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FAM62A shRNA (h) Lentiviral Particles - sc-95714-V from Santa Cruz Biotechnology
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ESYT1 - MBS8240068 from MyBioSource
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shRNA set against Human ESYT1 (NM_015292.2) - SHH287493 from Creative biogene
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Human ESYT1 siRNA - orb268697 from Biorbyt
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ESYT1 shRNA Plasmid (Human) - CHH8195 from Cohesion Biosciences
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ESYT1 miRNA 3'UTR clone - MiUTR3H-14764 from Creative biogene
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