| Gene Symbol |
AP4M1
|
| Entrez Gene |
9179
|
| Alt Symbol |
CPSQ3, MU-4, MU-ARP2, SPG50
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adaptor-related protein complex 4, mu 1 subunit
|
| Other Description |
AP-4 adaptor complex mu subunit|AP-4 complex subunit mu-1|adapter-related protein complex 4 mu-1 subunit|adapter-related protein complex 4 subunit mu-1|adaptor-related protein complex 4 subunit mu-1|adaptor-related protein complex AP-4 mu4 subunit|mu subunit of AP-4|mu-adaptin-related protein 2|mu-adaptin-related protein-2|mu4|mu4-adaptin
|
| Swissprots |
O00189 D6W5U1 Q9UHK9 Q8WV65
|
| Accessions |
EAL23854 EAW76594 EAW76595 EAW76596 EAW76597 O00189 AF020796 AAD25869 AF155158 AAD43328 AK055686 AK293590 BAG57057 AK296651 BAG59249 AK304489 BAG65298 AK315782 BC012023 BC018705 AAH18705 BX640759 CAE45865 DC413622 HQ447727 ADQ32212 Y08387 CAA69667 XM_005250689 XP_005250746 XM_005250690 XP_005250747 XM_006716175 XP_006716238 XM_011516685 XP_011514987 XM_011516686 XP_011514988 XM_011516687 XP_011514989 NM_004722 NP_004713
|
| Function |
Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal- lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP. {ECO:0000269|PubMed:11139587, ECO:0000269|PubMed:20230749}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung. {ECO:0000269|PubMed:10436028, ECO:0000269|PubMed:9013859}.
|
| Top Pathways |
Lysosome
|