AP4M1
| Gene Symbol | AP4M1 |
|---|---|
| Entrez Gene | 9179 |
| Alt Symbol | CPSQ3, MU-4, MU-ARP2, SPG50 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 4, mu 1 subunit |
| Other Description | AP-4 adaptor complex mu subunit|AP-4 complex subunit mu-1|adapter-related protein complex 4 mu-1 subunit|adapter-related protein complex 4 subunit mu-1|adaptor-related protein complex 4 subunit mu-1|adaptor-related protein complex AP-4 mu4 subunit|mu subunit of AP-4|mu-adaptin-related protein 2|mu-adaptin-related protein-2|mu4|mu4-adaptin |
| Swissprots | O00189 D6W5U1 Q9UHK9 Q8WV65 |
| Accessions | EAL23854 EAW76594 EAW76595 EAW76596 EAW76597 O00189 AF020796 AAD25869 AF155158 AAD43328 AK055686 AK293590 BAG57057 AK296651 BAG59249 AK304489 BAG65298 AK315782 BC012023 BC018705 AAH18705 BX640759 CAE45865 DC413622 HQ447727 ADQ32212 Y08387 CAA69667 XM_005250689 XP_005250746 XM_005250690 XP_005250747 XM_006716175 XP_006716238 XM_011516685 XP_011514987 XM_011516686 XP_011514988 XM_011516687 XP_011514989 NM_004722 NP_004713 |
| Function | Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal- lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP. {ECO:0000269|PubMed:11139587, ECO:0000269|PubMed:20230749}. |
| Subcellular Location | Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. |
| Tissue Specificity | Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung. {ECO:0000269|PubMed:10436028, ECO:0000269|PubMed:9013859}. |
| Top Pathways | Lysosome |
AP-4μ CRISPR/Cas9 KO Plasmid (h) - sc-408100 from Santa Cruz Biotechnology
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AP-4μ HDR Plasmid (h) - sc-408100-HDR from Santa Cruz Biotechnology
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AP-4μ Double Nickase Plasmid (h) - sc-408100-NIC from Santa Cruz Biotechnology
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AP-4μ Double Nickase Plasmid (h2) - sc-408100-NIC-2 from Santa Cruz Biotechnology
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AP-4μ CRISPR Activation Plasmid (h) - sc-408100-ACT from Santa Cruz Biotechnology
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AP-4μ CRISPR Activation Plasmid (h2) - sc-408100-ACT-2 from Santa Cruz Biotechnology
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AP-4μ Lentiviral Activation Particles (h) - sc-408100-LAC from Santa Cruz Biotechnology
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AP-4μ Lentiviral Activation Particles (h2) - sc-408100-LAC-2 from Santa Cruz Biotechnology
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AP-4μ siRNA (h) - sc-43616 from Santa Cruz Biotechnology
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AP-4μ shRNA Plasmid (h) - sc-43616-SH from Santa Cruz Biotechnology
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AP-4μ shRNA (h) Lentiviral Particles - sc-43616-V from Santa Cruz Biotechnology
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AP4M1 RNAi - H00009179-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN3301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3301 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01757 from Sigma-Aldrich
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AP4M1 siRNA (Human) - CRH6073 from Cohesion Biosciences
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AP4M1 - MBS8205129 from MyBioSource
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shRNA set against Human AP4M1 (NM_004722.3) - SHH237982 from Creative biogene
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shRNA set against Human AP4M1(NM_004722.3) - SHG064009 from Creative biogene
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Human AP4M1 siRNA - orb266575 from Biorbyt
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AP4M1 shRNA Plasmid (Human) - CHH6073 from Cohesion Biosciences
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AP4M1 miRNA 3'UTR clone - MiUTR1H-00446 from Creative biogene
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