Gene Symbol | FXYD1 |
---|---|
Entrez Gene | 5348 |
Alt Symbol | PLM |
Species | Human |
Gene Type | protein-coding |
Description | FXYD domain containing ion transport regulator 1 |
Other Description | phospholemman |
Swissprots | O00168 A8K196 |
Accessions | CAM55994 O00168 AA524547 AK289811 BAF82500 BC032800 AAH32800 BM691130 BM856555 BX115036 EU176238 ABW03689 EU176531 ABW03332 GQ258667 ACT90639 H57207 HY107209 HY111815 HY151101 HY151827 R46545 R72515 U72245 AAC51286 NM_001278717 NP_001265646 NM_001278718 NP_001265647 NM_005031 NP_005022 NM_021902 NP_068702 |
Function | May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis. |
Top Pathways | cAMP signaling pathway |
phospholemman CRISPR/Cas9 KO Plasmid (h) - sc-404959 from Santa Cruz Biotechnology
|
||||||||
phospholemman HDR Plasmid (h) - sc-404959-HDR from Santa Cruz Biotechnology
|
||||||||
phospholemman Double Nickase Plasmid (h) - sc-404959-NIC from Santa Cruz Biotechnology
|
||||||||
phospholemman Double Nickase Plasmid (h2) - sc-404959-NIC-2 from Santa Cruz Biotechnology
|
||||||||
phospholemman CRISPR Activation Plasmid (h) - sc-404959-ACT from Santa Cruz Biotechnology
|
||||||||
phospholemman CRISPR Activation Plasmid (h2) - sc-404959-ACT-2 from Santa Cruz Biotechnology
|
||||||||
phospholemman Lentiviral Activation Particles (h) - sc-404959-LAC from Santa Cruz Biotechnology
|
||||||||
phospholemman Lentiviral Activation Particles (h2) - sc-404959-LAC-2 from Santa Cruz Biotechnology
|
||||||||
phospholemman siRNA (h) - sc-106408 from Santa Cruz Biotechnology
|
||||||||
phospholemman shRNA Plasmid (h) - sc-106408-SH from Santa Cruz Biotechnology
|
||||||||
phospholemman shRNA (h) Lentiviral Particles - sc-106408-V from Santa Cruz Biotechnology
|
||||||||
Phospholemman RNAi - H00005348-R02 from Novus Biologicals
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN9011 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9011 from Sigma-Aldrich
|
||||||||
FXYD1 siRNA (Human) - CRH3587 from Cohesion Biosciences
|
||||||||
Phospholemman RNAi - H00005348-R01 from Novus Biologicals
|
||||||||
FXYD1 - MBS8226172 from MyBioSource
|
||||||||
shRNA set against Human FXYD1 (NM_005031.3) - SHH297921 from Creative biogene
|
||||||||
shRNA set against Human FXYD1(NM_005031.3) - SHH071273 from Creative biogene
|
||||||||
Human FXYD1 siRNA - orb264089 from Biorbyt
|
||||||||
FXYD1 shRNA Plasmid (Human) - CHH3587 from Cohesion Biosciences
|
||||||||
FXYD1 miRNA 3'UTR clone - MiUTR1H-03886 from Creative biogene
|
||||||||
FXYD1 miRNA 3'UTR clone - MiUTR3H-04908 from Creative biogene
|