| Gene Symbol |
OASL
|
| Entrez Gene |
8638
|
| Alt Symbol |
OASLd, TRIP-14, TRIP14, p59 OASL, p59-OASL, p59OASL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
2'-5'-oligoadenylate synthetase-like
|
| Other Description |
2'-5'-OAS-RP|2'-5'-OAS-related protein|2'-5'-oligoadenylate synthase-like protein|59 kDa 2'-5'-oligoadenylate synthase-like protein|59 kDa 2'-5'-oligoadenylate synthetase-like protein|TR-interacting protein 14|thyroid receptor-interacting protein 14
|
| Swissprots |
Q9Y6K6 O75686 I1YDD2 B2RAZ2 Q17R95 Q9Y6K7 Q15646
|
| Accessions |
AAC41733 EAW98235 EAW98236 EAW98237 EAW98238 Q15646 AJ225089 CAA12396 AK023956 BAG51241 AK314419 BAG37039 AL711263 AW069118 BC117408 AAI17409 BC117410 AAI17411 BG339739 BG744291 BM909951 BM918192 DB005346 HQ258301 ADR83055 JQ792168 AFJ00074 NM_001261825 NP_001248754 NM_003733 NP_003724 NM_198213 NP_937856
|
| Function |
Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559, ECO:0000269|PubMed:9826176}.
|
| Subcellular Location |
Isoform p56: Nucleus, nucleolus. Cytoplasm.
|
| Tissue Specificity |
Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.
|
![Western Blot: OASL Overexpression Lysate (Adult Normal) [NBP2-07962] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OASL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9913_OASL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07962-img0001.jpg)