OASL

Gene Symbol OASL
Entrez Gene 8638
Alt Symbol OASLd, TRIP-14, TRIP14, p59 OASL, p59-OASL, p59OASL
Species Human
Gene Type protein-coding
Description 2'-5'-oligoadenylate synthetase-like
Other Description 2'-5'-OAS-RP|2'-5'-OAS-related protein|2'-5'-oligoadenylate synthase-like protein|59 kDa 2'-5'-oligoadenylate synthase-like protein|59 kDa 2'-5'-oligoadenylate synthetase-like protein|TR-interacting protein 14|thyroid receptor-interacting protein 14
Swissprots Q9Y6K6 O75686 I1YDD2 B2RAZ2 Q17R95 Q9Y6K7 Q15646
Accessions AAC41733 EAW98235 EAW98236 EAW98237 EAW98238 Q15646 AJ225089 CAA12396 AK023956 BAG51241 AK314419 BAG37039 AL711263 AW069118 BC117408 AAI17409 BC117410 AAI17411 BG339739 BG744291 BM909951 BM918192 DB005346 HQ258301 ADR83055 JQ792168 AFJ00074 NM_001261825 NP_001248754 NM_003733 NP_003724 NM_198213 NP_937856
Function Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559, ECO:0000269|PubMed:9826176}.
Subcellular Location Isoform p56: Nucleus, nucleolus. Cytoplasm.
Tissue Specificity Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

OASL (H-200) - sc-98313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OASL (H-200): sc-98313. Western blot analysis of OASL expression in HL-60 whole cell lysate.

OASL (N-12) - sc-107831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OASL (N-12): sc-107831. Western blot analysis of OASL expression in human tonsil tissue extract.

OASL (T-14) - sc-107832 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OASL (L-25) - sc-130832 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
OASL (L-25): sc-130832. Western blot analysis of OASL expression in HL-60 (A), U-251-MG (B), HCT-116 (C) and HeLa (D) whole cell lysates and human liver (E) and human tonsil (F) tissue extracts.

Anti-OASL antibody - ab86124 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-OASL antibody (ab86124) at 1 µg/ml + Fetal brain lysate (Human) at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-OASL antibody - ab155422 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-OASL antibody (ab155422) at 1/1000 dilution + U87-MG whole cell lysate at 30 µg

Anti-OASL antibody - Carboxyterminal end - ab38325 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab38325 stained HCT116 cells. The cells were 100% methanol fixed for 5 minutes at room temperature and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab38325 at 5µg/ml) overnight at +4°C. The secondary antibody (pseudo-colored green) was ab150081 used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-OASL antibody - N-terminal - ab191701 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-OASL antibody - N-terminal (ab191701) at 1 µg/ml + mouse bladder tissue lysate at 15 µg

Anti-OASL Antibody (N-Terminus) IHC-plus™ - LS-B12062 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-OASL Antibody (aa484-514) - LS-C100477 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-OASL Antibody (aa499-514) - LS-C3146 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OASL Antibody (C-Terminus, AP) - LS-C280365 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OASL Antibody (C-Terminus, APC) - LS-C280366 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OASL Antibody (C-Terminus, FITC) - LS-C280367 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OASL Antibody (C-Terminus, Azide-free, HRP) - LS-C280369 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OASL Antibody (C-Terminus, Biotin) - LS-C280368 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OASL Antibody (C-Terminus) - LS-C328088 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OASL Antibody (C-Terminus, PE) - LS-C280370 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

OASL Antibody - NBP2-19618 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OASL Antibody [NBP2-19618] - Sample (30 ug of whole cell lysate) A: HCT116 7. 5% SDS PAGE gel, diluted at 1:2000.

OASL Antibody - NBP1-87363 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OASL Antibody [NBP1-87363] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

OASL Antibody - NBP2-19619 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OASL Antibody [NBP2-19619] - Sample (30 ug of whole cell lysate) A: U87-MG 7. 5% SDS PAGE gel, diluted at 1:1000.

Anti-OASL antibody produced in rabbit - HPA001474 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OASL: <B>Cat. No. HPA001474</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human testis tissue showing cytoplasmic and/or membranous staining of cells in ductus seminiferus.

Anti-OASL antibody produced in rabbit - SAB2101671 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-OASL antibody produced in rabbit - SAB2104543 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-OASL, antibody produced in rabbit: <B>Cat. No. SAB2104543</B>: Immunoblotting analysis of OASL in NCI-H226 cell lysate with OASL anitbody at 1 μg/mL.

OASL-Antibody-C-term - AP6230a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from HT-29, PC-3, U-87 MG cell line and human testis tissue lysate(from left to right), using OASL Antibody T499(Cat. #AP6230a). AP6230a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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