Gene Symbol | OASL |
---|---|
Entrez Gene | 8638 |
Alt Symbol | OASLd, TRIP-14, TRIP14, p59 OASL, p59-OASL, p59OASL |
Species | Human |
Gene Type | protein-coding |
Description | 2'-5'-oligoadenylate synthetase-like |
Other Description | 2'-5'-OAS-RP|2'-5'-OAS-related protein|2'-5'-oligoadenylate synthase-like protein|59 kDa 2'-5'-oligoadenylate synthase-like protein|59 kDa 2'-5'-oligoadenylate synthetase-like protein|TR-interacting protein 14|thyroid receptor-interacting protein 14 |
Swissprots | Q9Y6K6 O75686 I1YDD2 B2RAZ2 Q17R95 Q9Y6K7 Q15646 |
Accessions | AAC41733 EAW98235 EAW98236 EAW98237 EAW98238 Q15646 AJ225089 CAA12396 AK023956 BAG51241 AK314419 BAG37039 AL711263 AW069118 BC117408 AAI17409 BC117410 AAI17411 BG339739 BG744291 BM909951 BM918192 DB005346 HQ258301 ADR83055 JQ792168 AFJ00074 NM_001261825 NP_001248754 NM_003733 NP_003724 NM_198213 NP_937856 |
Function | Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559, ECO:0000269|PubMed:9826176}. |
Subcellular Location | Isoform p56: Nucleus, nucleolus. Cytoplasm. |
Tissue Specificity | Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis. |
OASL CRISPR/Cas9 KO Plasmid (h) - sc-417005 from Santa Cruz Biotechnology
|
||||||||
OASL HDR Plasmid (h) - sc-417005-HDR from Santa Cruz Biotechnology
|
||||||||
OASL Double Nickase Plasmid (h) - sc-417005-NIC from Santa Cruz Biotechnology
|
||||||||
OASL Double Nickase Plasmid (h2) - sc-417005-NIC-2 from Santa Cruz Biotechnology
|
||||||||
OASL CRISPR Activation Plasmid (h) - sc-417005-ACT from Santa Cruz Biotechnology
|
||||||||
OASL CRISPR Activation Plasmid (h2) - sc-417005-ACT-2 from Santa Cruz Biotechnology
|
||||||||
OASL Lentiviral Activation Particles (h) - sc-417005-LAC from Santa Cruz Biotechnology
|
||||||||
OASL Lentiviral Activation Particles (h2) - sc-417005-LAC-2 from Santa Cruz Biotechnology
|
||||||||
OASL siRNA (h) - sc-95857 from Santa Cruz Biotechnology
|
||||||||
OASL shRNA Plasmid (h) - sc-95857-SH from Santa Cruz Biotechnology
|
||||||||
OASL shRNA (h) Lentiviral Particles - sc-95857-V from Santa Cruz Biotechnology
|
||||||||
OASL RNAi - H00008638-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU076721 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN15666 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15666 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR07136 from Sigma-Aldrich
|
||||||||
OASL siRNA (Human) - CRH5677 from Cohesion Biosciences
|
||||||||
OASL RNAi - H00008638-R02 from Novus Biologicals
|
||||||||
shRNA set against Human OASL (NM_003733.3) - SHH357000 from Creative biogene
|
||||||||
Human OASL siRNA - orb266179 from Biorbyt
|
||||||||
OASL shRNA Plasmid (Human) - CHH5677 from Cohesion Biosciences
|
||||||||
OASL miRNA 3'UTR clone - MiUTR4H-TG06208 from Creative biogene
|