| Gene Symbol |
HS6ST1
|
| Entrez Gene |
9394
|
| Alt Symbol |
HH15, HS6ST
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heparan sulfate 6-O-sulfotransferase 1
|
| Other Description |
HS6ST-1|heparan-sulfate 6-O-sulfotransferase 1|heparan-sulfate 6-sulfotransferase
|
| Swissprots |
O60243 B4DJ29 B4DEP2 Q9BVI1 Q53SL2
|
| Accessions |
AAY14736 EAW95357 EAW95358 EAW95359 O60243 AB006179 BAA25760 AK058121 AK293724 BAG57153 AK295898 BAG58691 AK304326 BAG65175 AL831893 BC001196 AAH01196 BC019025 BC047087 BC063521 BC096239 AAH96239 BC096240 AAH96240 BC099638 AAH99638 BC099639 AAH99639 BP219645 CV569969 DR005030 NM_004807 NP_004798
|
| Function |
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269|PubMed:21700882}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in fetal brain. {ECO:0000269|PubMed:9535912}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|
![Western Blot: HS6ST1 Overexpression Lysate (Adult Normal) [NBP2-07824] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HS6ST1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4064_HS6ST1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07824-img0001.jpg)