Gene Symbol | HS6ST1 |
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Entrez Gene | 9394 |
Alt Symbol | HH15, HS6ST |
Species | Human |
Gene Type | protein-coding |
Description | heparan sulfate 6-O-sulfotransferase 1 |
Other Description | HS6ST-1|heparan-sulfate 6-O-sulfotransferase 1|heparan-sulfate 6-sulfotransferase |
Swissprots | O60243 B4DJ29 B4DEP2 Q9BVI1 Q53SL2 |
Accessions | AAY14736 EAW95357 EAW95358 EAW95359 O60243 AB006179 BAA25760 AK058121 AK293724 BAG57153 AK295898 BAG58691 AK304326 BAG65175 AL831893 BC001196 AAH01196 BC019025 BC047087 BC063521 BC096239 AAH96239 BC096240 AAH96240 BC099638 AAH99638 BC099639 AAH99639 BP219645 CV569969 DR005030 NM_004807 NP_004798 |
Function | 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269|PubMed:21700882}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in fetal brain. {ECO:0000269|PubMed:9535912}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
HS6ST1 CRISPR/Cas9 KO Plasmid (h) - sc-405111 from Santa Cruz Biotechnology
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HS6ST1 HDR Plasmid (h) - sc-405111-HDR from Santa Cruz Biotechnology
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HS6ST1 Double Nickase Plasmid (h) - sc-405111-NIC from Santa Cruz Biotechnology
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HS6ST1 Double Nickase Plasmid (h2) - sc-405111-NIC-2 from Santa Cruz Biotechnology
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HS6ST1 CRISPR Activation Plasmid (h) - sc-405111-ACT from Santa Cruz Biotechnology
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HS6ST1 CRISPR Activation Plasmid (h2) - sc-405111-ACT-2 from Santa Cruz Biotechnology
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HS6ST1 Lentiviral Activation Particles (h) - sc-405111-LAC from Santa Cruz Biotechnology
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HS6ST1 Lentiviral Activation Particles (h2) - sc-405111-LAC-2 from Santa Cruz Biotechnology
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HS6ST1 siRNA (h) - sc-94375 from Santa Cruz Biotechnology
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HS6ST1 shRNA Plasmid (h) - sc-94375-SH from Santa Cruz Biotechnology
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HS6ST1 shRNA (h) Lentiviral Particles - sc-94375-V from Santa Cruz Biotechnology
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Heparan Sulfate 6-O-Sulfotransferase 1/HS6ST1 RNAi - H00009394-R01 from Novus Biologicals
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MISSION® esiRNA - EHU104791 from Sigma-Aldrich
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MISSION® esiRNA - EHU111771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10313 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10313 from Sigma-Aldrich
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HS6ST1 siRNA (Human) - CRH6226 from Cohesion Biosciences
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HS6ST1 - MBS8202834 from MyBioSource
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shRNA set against Human HS6ST1(NM_004807.2) - SHH131879 from Creative biogene
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HS6ST1 shRNA Plasmid (Human) - CHH6226 from Cohesion Biosciences
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HS6ST1 miRNA 3'UTR clone - MiUTR1H-04707 from Creative biogene
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