| Gene Symbol |
NGB
|
| Entrez Gene |
58157
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuroglobin
|
| Other Description |
-
|
| Swissprots |
Q9NPG2
|
| Accessions |
AAF62557 AAF63183 AAL98923 AAY16983 CAC12994 EAW81274 EAW81275 Q9NPG2 AF422797 AAL98924 AJ245946 CAC11133 AK098350 AK315395 BAG37788 BC032509 AAH32509 DQ890861 ABM81787 DQ894016 ABM84942 NM_021257 NP_067080
|
| Function |
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. {ECO:0000269|PubMed:11029004, ECO:0000269|PubMed:11473128, ECO:0000269|PubMed:18416560, ECO:0000269|PubMed:21190290, ECO:0000269|PubMed:21296891}.
|
| Subcellular Location |
Perikaryon {ECO:0000250}. Cytoplasm. Mitochondrion.
|
| Tissue Specificity |
Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus. {ECO:0000269|PubMed:11029004}.
|
![Western Blot: Neuroglobin Overexpression Lysate (Adult Normal) [NBL1-13631] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Neuroglobin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7826_Neuroglobin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13631-img0002.jpg)