NGB

Gene Symbol	NGB
Entrez Gene	58157
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	neuroglobin
Other Description	-
Swissprots	Q9NPG2
Accessions	AAF62557 AAF63183 AAL98923 AAY16983 CAC12994 EAW81274 EAW81275 Q9NPG2 AF422797 AAL98924 AJ245946 CAC11133 AK098350 AK315395 BAG37788 BC032509 AAH32509 DQ890861 ABM81787 DQ894016 ABM84942 NM_021257 NP_067080
Function	Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. {ECO:0000269\|PubMed:11029004, ECO:0000269\|PubMed:11473128, ECO:0000269\|PubMed:18416560, ECO:0000269\|PubMed:21190290, ECO:0000269\|PubMed:21296891}.
Subcellular Location	Perikaryon {ECO:0000250}. Cytoplasm. Mitochondrion.
Tissue Specificity	Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus. {ECO:0000269\|PubMed:11029004}.

neuroglobin (E-16) - sc-22001 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

neuroglobin (FL-151) - sc-30144 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

neuroglobin (FL-151): sc-30144. Western blot analysis of neuroglobin expression in non-transfected: sc-110760 (A) and human neuroglobin transfected: sc-110715 (B) whole cell lysates.

neuroglobin (G-11) - sc-133086 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

neuroglobin (G-11): sc-133086. Western blot analysis of neuroglobin expression in non-transfected: sc-117752 (A) and human neuroglobin transfected: sc-110715 (B) 293T whole cell lysates.

Anti-Neuroglobin antibody - ab14010 from Abcam

Host	Chicken
Clonality	Polyclonal

Anti-Neuroglobin antibody [13C8] - ab37258 from Abcam

Prices	$384.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	13C8

Overlay histogram showing SH-SY5Y cells stained with ab37258 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab37258, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-NGB / Neuroglobin Antibody - LS-C73272 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-NGB / Neuroglobin Antibody - LS-C73273 from LifeSpan Bioscience

Prices	$425.00
Sizes	50 µg
Host	Chicken
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody - LS-C211464 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (HRP) - LS-C211468 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (FITC) - LS-C211470 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (Biotin) - LS-C211471 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody - LS-C318247 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (HRP) - LS-C318245 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (FITC) - LS-C318248 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (Biotin) - LS-C318249 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody - LS-C136955 from LifeSpan Bioscience

Prices	$255.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (aa1-30) - LS-C323328 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (clone 1A11-A9) - LS-C139440 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1A11-A9

Detection limit for recombinant GST tagged NGB is approximately 0.1 ng/ml as a capture antibody.

Anti-NGB / Neuroglobin Antibody (clone 13C8) - LS-C340753 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	13C8

Anti-NGB / Neuroglobin Antibody - LS-C340813 from LifeSpan Bioscience

Prices	$285.00
Sizes	50 µg
Host	Chicken
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody (aa1-151) - LS-C314562 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant NGB / Neuroglobin.

Anti-NGB / Neuroglobin Antibody (aa1-151) - LS-C314561 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NGB / Neuroglobin Antibody - LS-C334745 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using NGB antibody.

Neuroglobin Antibody (2B5-A7) - H00058157-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2B5-A7

Neuroglobin Antibody (1A11-A9) - H00058157-M02 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1A11-A9

Sandwich ELISA: Neuroglobin Antibody (1A11-A9) [H00058157-M02] - Detection limit for recombinant GST tagged NGB is approximately 0.1ng/ml as a capture antibody.

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