VPS26B

Gene Symbol VPS26B
Entrez Gene 112936
Alt Symbol Pep8b
Species Human
Gene Type protein-coding
Description vacuolar protein sorting 26 homolog B (S. pombe)
Other Description vacuolar protein sorting-associated protein 26B|vesicle protein sorting 26B
Swissprots Q96A55 Q4G0F5
Accessions EAW67825 EAW67826 EAW67827 Q4G0F5 AF452718 AAP13353 AV735504 BC007799 BC009747 AAH09747 BC013255 BC014128 AAH14128 BC098386 AAH98386 CD369199 EU176371 ABW03822 EU176709 ABW03510 XM_011542565 XP_011540867 NM_052875 NP_443107
Function Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26
Subcellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}. Early endosome {ECO:0000250|UniProtKB:Q8C0E2}. Late endosome {ECO:0000250|UniProtKB:Q8C0E2}. Note=Localizes to early and late endosomal structures (By similarity). {ECO:0000250|UniProtKB:Q8C0E2}.

VP26B Overexpression Lysate (Native) - NBP2-05846 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: VP26B Overexpression Lysate (Adult Normal) [NBP2-05846] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VP26B.

Panoply™ Human VPS26B Knockdown Stable Cell Line - CSC-DC017311 from Creative biogene

Category Cell Line
Species Human
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