VPS26B
| Gene Symbol | VPS26B |
|---|---|
| Entrez Gene | 112936 |
| Alt Symbol | Pep8b |
| Species | Human |
| Gene Type | protein-coding |
| Description | vacuolar protein sorting 26 homolog B (S. pombe) |
| Other Description | vacuolar protein sorting-associated protein 26B|vesicle protein sorting 26B |
| Swissprots | Q96A55 Q4G0F5 |
| Accessions | EAW67825 EAW67826 EAW67827 Q4G0F5 AF452718 AAP13353 AV735504 BC007799 BC009747 AAH09747 BC013255 BC014128 AAH14128 BC098386 AAH98386 CD369199 EU176371 ABW03822 EU176709 ABW03510 XM_011542565 XP_011540867 NM_052875 NP_443107 |
| Function | Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26 |
| Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}. Early endosome {ECO:0000250|UniProtKB:Q8C0E2}. Late endosome {ECO:0000250|UniProtKB:Q8C0E2}. Note=Localizes to early and late endosomal structures (By similarity). {ECO:0000250|UniProtKB:Q8C0E2}. |
VPS26B CRISPR/Cas9 KO Plasmid (h) - sc-410249 from Santa Cruz Biotechnology
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VPS26B HDR Plasmid (h) - sc-410249-HDR from Santa Cruz Biotechnology
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VPS26B Double Nickase Plasmid (h) - sc-410249-NIC from Santa Cruz Biotechnology
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VPS26B Double Nickase Plasmid (h2) - sc-410249-NIC-2 from Santa Cruz Biotechnology
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VPS26B CRISPR Activation Plasmid (h) - sc-410249-ACT from Santa Cruz Biotechnology
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VPS26B CRISPR Activation Plasmid (h2) - sc-410249-ACT-2 from Santa Cruz Biotechnology
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VPS26B Lentiviral Activation Particles (h) - sc-410249-LAC from Santa Cruz Biotechnology
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VPS26B Lentiviral Activation Particles (h2) - sc-410249-LAC-2 from Santa Cruz Biotechnology
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VPS26B siRNA (h) - sc-96405 from Santa Cruz Biotechnology
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VPS26B shRNA Plasmid (h) - sc-96405-SH from Santa Cruz Biotechnology
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VPS26B shRNA (h) Lentiviral Particles - sc-96405-V from Santa Cruz Biotechnology
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VP26B RNAi - H00112936-R01 from Novus Biologicals
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MISSION® esiRNA - EHU047241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22714 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22714 from Sigma-Aldrich
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VPS26B siRNA (Human) - CRJ4299 from Cohesion Biosciences
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VPS26B - MBS8221340 from MyBioSource
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shRNA set against Human VPS26B (NM_052875.3) - SHH444892 from Creative biogene
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shRNA set against Human VPS26B(NM_052875.3) - SHL127560 from Creative biogene
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VPS26B CRISPR/Cas9 KO Plasmid (h2) - sc-410249-KO-2 from Santa Cruz Biotechnology
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VPS26B HDR Plasmid (h2) - sc-410249-HDR-2 from Santa Cruz Biotechnology
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VPS26B shRNA Plasmid (Human) - CHJ4299 from Cohesion Biosciences
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VPS26B miRNA 3'UTR clone - MiUTR1H-11146 from Creative biogene
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