BCL11B
| Gene Symbol | BCL11B |
|---|---|
| Entrez Gene | 64919 |
| Alt Symbol | ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, RIT1, ZNF856B, hRIT1-alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | B-cell CLL/lymphoma 11B (zinc finger protein) |
| Other Description | B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein|B-cell lymphoma/leukaemia 11B|B-cell lymphoma/leukemia 11B|BCL-11B|BCL11B/TRDC fusion|COUP-TF-interacting protein 2|hRit1|radiation-induced tumor suppressor gene 1 protein|zinc finger protein hRit1 alpha |
| Swissprots | Q9C0K0 Q9H162 |
| Accessions | BAM78533 CAX20397 EAW81662 EAW81663 Q9C0K0 AB041218 BAM78282 AB043584 BAB32731 AB057668 BAM78283 AB057669 BAM78284 AB057670 BAM78285 AF086271 AJ404614 CAC17726 BC156139 AAI56140 XM_011537100 XP_011535402 NM_001282237 NP_001269166 NM_001282238 NP_001269167 NM_022898 NP_075049 NM_138576 NP_612808 |
| Function | Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma. |
Bcl-11b CRISPR/Cas9 KO Plasmid (h) - sc-403460 from Santa Cruz Biotechnology
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Bcl-11b HDR Plasmid (h) - sc-403460-HDR from Santa Cruz Biotechnology
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Bcl-11b Double Nickase Plasmid (h) - sc-403460-NIC from Santa Cruz Biotechnology
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Bcl-11b Double Nickase Plasmid (h2) - sc-403460-NIC-2 from Santa Cruz Biotechnology
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Bcl-11b CRISPR Activation Plasmid (h) - sc-403460-ACT from Santa Cruz Biotechnology
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Bcl-11b CRISPR Activation Plasmid (h2) - sc-403460-ACT-2 from Santa Cruz Biotechnology
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Bcl-11b Lentiviral Activation Particles (h) - sc-403460-LAC from Santa Cruz Biotechnology
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Bcl-11b Lentiviral Activation Particles (h2) - sc-403460-LAC-2 from Santa Cruz Biotechnology
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Bcl-11b siRNA (h) - sc-43579 from Santa Cruz Biotechnology
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Bcl-11b shRNA Plasmid (h) - sc-43579-SH from Santa Cruz Biotechnology
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Bcl-11b shRNA (h) Lentiviral Particles - sc-43579-V from Santa Cruz Biotechnology
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SPG3A RNAi - H00051062-R03 from Novus Biologicals
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Rit1 RNAi - H00006016-R01 from Novus Biologicals
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BCL11B RNAi - H00064919-R01 from Novus Biologicals
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MISSION® esiRNA - EHU082941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3906 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3906 from Sigma-Aldrich
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BCL11B siRNA (Human) - CRJ2137 from Cohesion Biosciences
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BCL11B RNAi - H00064919-R02 from Novus Biologicals
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BCL11B - MBS8228331 from MyBioSource
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shRNA set against Human Bcl11b (NM_022898.1) - SHH245870 from Creative biogene
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shRNA set against Human BCL11B(NM_022898.1) - SHG096721 from Creative biogene
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shRNA set against Human BCL11B(NM_138576.2) - SHG096893 from Creative biogene
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shRNA set against Human BCL11B(NM_022898.1) - SHG096929 from Creative biogene
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BCL11B shRNA Plasmid (Human) - CHJ2137 from Cohesion Biosciences
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