| Gene Symbol |
APOBEC3B
|
| Entrez Gene |
9582
|
| Alt Symbol |
A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
|
| Other Description |
DNA dC->dU-editing enzyme APOBEC-3B|apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B|cytidine deaminase|phorbolin 2|phorbolin 3|phorbolin-1-related protein|phorbolin-2/3|probable DNA dC->dU-editing enzyme APOBEC-3B
|
| Swissprots |
O95618 Q9UH17 Q7Z2N3 Q9UE74 Q5IFJ4 Q20WL1 Q7Z6D6 B0QYD2
|
| Accessions |
EAW60279 EAW60280 EAW60281 EAW60282 Q9UH17 AK024854 AU098564 AY743217 AAW31743 BC031803 BC053859 AAH53859 BX114955 CT841510 CAJ86440 CU012951 CAK54382 CU013031 CAK54462 CU013239 CAK54681 CU013319 CAK54761 KF651167 AHF72554 U61083 AAD00089 U61084 AAD00090 NM_001270411 NP_001257340 NM_004900 NP_004891
|
| Function |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of L
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:18667511, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22915799}.
|
| Tissue Specificity |
Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:20308164}.
|