APOBEC3B

Gene Symbol APOBEC3B
Entrez Gene 9582
Alt Symbol A3B, APOBEC1L, ARCD3, ARP4, DJ742C19.2, PHRBNL, bK150C2.2
Species Human
Gene Type protein-coding
Description apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
Other Description DNA dC->dU-editing enzyme APOBEC-3B|apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B|cytidine deaminase|phorbolin 2|phorbolin 3|phorbolin-1-related protein|phorbolin-2/3|probable DNA dC->dU-editing enzyme APOBEC-3B
Swissprots O95618 Q9UH17 Q7Z2N3 Q9UE74 Q5IFJ4 Q20WL1 Q7Z6D6 B0QYD2
Accessions EAW60279 EAW60280 EAW60281 EAW60282 Q9UH17 AK024854 AU098564 AY743217 AAW31743 BC031803 BC053859 AAH53859 BX114955 CT841510 CAJ86440 CU012951 CAK54382 CU013031 CAK54462 CU013239 CAK54681 CU013319 CAK54761 KF651167 AHF72554 U61083 AAD00089 U61084 AAD00090 NM_001270411 NP_001257340 NM_004900 NP_004891
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of L
Subcellular Location Nucleus {ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:18667511, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22915799}.
Tissue Specificity Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:20308164}.

APOBEC3A/B (H-89) - sc-292434 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

APOBEC3B (H-22) - sc-130955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
APOBEC3B (H-22): sc-130955. Western blot analysis of APOBEC3B expression in Hep G2 whole cell lysate.

Anti-APOBEC3B antibody - ab69895 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-APOBEC3B antibody (ab69895) at 1/500 dilutionLane 1 : APOBEC3B transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-APOBEC3B antibody - ab104759 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-APOBEC3B antibody (ab104759) at 0.25 µg/ml + HepG2 cell lysate at 10 µg

Anti-APOBEC3B antibody - N-terminal - ab191695 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-APOBEC3B antibody - N-terminal (ab191695) at 1 µg/ml + rat small intestine tissue lysate at 15 µgdeveloped using the ECL technique

Anti-APOBEC3B Antibody (aa307-337, AP) - LS-C232756 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3B Antibody (aa307-337, APC) - LS-C232757 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3B Antibody (aa307-337, Biotin) - LS-C232758 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3B Antibody (aa307-337, PE) - LS-C232761 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3B Antibody (aa307-337, Azide-free, HRP) - LS-C249442 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3B Antibody (aa307-337, FITC) - LS-C232759 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3B Antibody - LS-C306292 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-APOBEC3B Antibody (aa307-337) - LS-C319542 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-APOBEC3B Antibody (aa78-127) - LS-C80830 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-APOBEC3B Antibody (aa299-330) - LS-C98891 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of hPHO3-D314 in mouse testis tissue lysates (35 ug/lane). PHO3 (arrow) was detected using the purified antibody.

Anti-APOBEC3B Antibody (N-Terminus) IHC-plus™ - LS-B12051 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)

APOBEC3B Antibody - NBP1-57516 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: APOBEC3B Antibody [NBP1-57516] - Sample Tissue: HepG2, Lane A: Primary Antibody, Lane B: Primary Antibody + Blocking Peptide, Primary Antibody Concentration: 1ug/ml, Peptide Concentration: 5ug/ml, Lysate Quantity: 25ug/lane/lane, Gel Concentration: 0.12

APOBEC3B Antibody - H00009582-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: APOBEC3B Antibody [H00009582-B01P] - analysis of APOBEC3B expression in transfected 293T cell line by APOBEC3B MaxPab polyclonal antibody. Lane 1: APOBEC3B transfected lysate (27.61 KDa). Lane 2: Non-transfected lysate.

APOBEC3B Polyclonal Antibody - bs-12494R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Jurkat Cell lysates; probed with APOBEC3B Polyclonal Antibody, unconjugated (bs-12494R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.

APOBEC3B Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12494R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APOBEC3B Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12494R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APOBEC3B Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12494R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APOBEC3B Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12494R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APOBEC3B Polyclonal Antibody, Cy3 Conjugated - bs-12494R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APOBEC3B Polyclonal Antibody, Cy5 Conjugated - bs-12494R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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